Vikings vs. Bills Prediction and Odds for NFL Week 10 (Buffalo Will Expose Minnesota's Fraudulent Record)

Nov 6, 2022; East Rutherford, NJ, USA; Buffalo Bills quarterback Josh Allen (17) throws in the first
Nov 6, 2022; East Rutherford, NJ, USA; Buffalo Bills quarterback Josh Allen (17) throws in the first / Robert Deutsch-USA TODAY Sports

The Minnesota Vikings are 7-1 on the season and firmly in first place in the NFC North.

Now, they'll face their toughest test of the season in the Buffalo Bills, who are coming off one of the biggest upsets of the season when they lost to the New York Jets as 12.5-point favorites.

Can the Vikings stay hot? Will the Bills get back on track?

Let's dive into the betting odds for this marquee interconference matchup.

Vikings vs. Bills Odds, Spread, and Total

Vikings vs. Bills Betting Trends

  • The OVER is 11-5 in the Vikings' last 16 games
  • Vikings are 6-2 ATS in last eight games against AFC East opponents
  • Vikings are 2-4 ATS in last six games against Bills
  • The UNDER is 6-0 in the Bills last six games
  • The UNDER is 8-1 in the Bills last nine games against NFC North opponents
  • Bills are 11-4-1 ATS in their last 16 games played in November

Vikings vs. Bills Prediction and Pick

It's time to fade the Vikings. Despite their impressive record, they rank 22nd in the NFL in net yards per play at -0.4. It's near impossible to keep up a one loss record while recording negative net yards per play.

Meanwhile, the Bills are first in net yards per play by a wide margin at +1.5.

Josh Allen and the Bills offense should have a field day against this Vikings defense that allows 7.4 yards per pass attempt, the third highest mark in the NFL. They're also 27th in opponent completion percentage and 26th in opponent yards per completion.

Most importantly, they rank dead last in opponent red zone touchdown percentage, allowing teams to score a touchdown 78.95% of the time they enter the red zone.

Not enough can be said about the Buffalo Bills. Don't overreact to their loss to the Jets, teams will occasionally lose games that they shouldn't lose. It happens every season. Trust Buffalo to bounce back in a big way in Week 10.

You can track Iain's bets on Betstamp here.

Game odds refresh periodically and are subject to change.