Xavier vs. DePaul Prediction and Odds (Bet on Blue Demons to Regress After Beating Seton Hall)

The Xavier Musketeers are gunning for their second win in a row when they take on the DePaul Blue Demons on the road.
The Xavier Musketeers are gunning for their second win in a row when they take on the DePaul Blue Demons on the road. / Cara Owsley/The Enquirer / USA TODAY

The Big East is back in action when the No. 20 Xavier Musketeers head to face the DePaul Blue Demons in Chicago. Xavier is entering Wednesday night coming off a home victory over Creighton Saturday night 80-73.

The win couldn’t have come at a better time as the Musketeers had lost two of three after starting the season 11-1. 

DePaul, meanwhile, had a similar bounce-back win their last time out. After losing five games in a row, the Blue Demons came out and shocked No. 20 Seton Hall 96-92.

It was a result that nobody saw coming. Because of that, now DePaul is just a 7.5 point underdog against the new No. 20 teams in the nation. This, despite being the 10th ranked team in the Big East with a 10-6 overall record and just one win since Dec. 14, 2010.

Seems like a bit of recency bias to me. Here are the odds for this important Big East matchup, courtesy of WynnBET Sportsbook.

Xavier vs. DePaul Odds, Spread, and Total


  • Xavier -7.5 (-110)
  • DePaul +7.5 (-110)


  • Xavier -330
  • DePaul +225

Total: 151 (Over -110/Under -110)

Xavier vs. DePaul Prediction and Pick

I am choosing to look at the DePaul win over Seton Hall as exactly what it was. A fluke win. While the Blue Demons have a good record as underdogs against the spread at 5-3, they are not a team that can beat a top 20 team on a regular basis. 

The Musketeers are looking to regain the winning magic they had early on in the season when they went 11-1.  I am seeing some of that magic again after watching them beat Creighton and move to 13-3.

The Musketeers dominated the turnover game with 21 total and came back from five down to go on a 19-4 run to win the game. On the year. Xavier is averaging a decent 75.6 points per game, which ranks them in the top 100. Xavier’s defense is their bread and butter and ranks 52nd in the nation in scoring defense.

I think this will be a test for Xavier. But a test that it will pass with flying colors. I’m betting on the road team to eke out a close game for their second victory in a row. 

Pick: Xavier -7.5