49ers vs. Broncos Best Prop Bets for Sunday Night Football (Expect Defense to Reign Supreme)

Sep 11, 2022; Chicago, Illinois, USA; San Francisco 49ers defensive end Nick Bosa (97) during the
Sep 11, 2022; Chicago, Illinois, USA; San Francisco 49ers defensive end Nick Bosa (97) during the / Mike Dinovo-USA TODAY Sports
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The San Francisco 49ers and Denver Broncos will meet each other in the NFL Week 3 edition of Sunday Night Football.

Both teams have a lot of intriguing storylines surrounding them. How will Jimmy G perform now that he's back in the starter role for the 49ers? Can Russell Wilson and the Broncos finally get some momentum going in the right direction?

If you want the odds and our best bet for the game, check out our betting preview here.

In this article, I'm going to give you my favorite prop bets for tonight's prime time showdown.

Best Prop Bets for 49ers vs. Broncos Week 3

  • Javonte Williams UNDER 49.5 Rushing Yards (-115)
  • Jimmy Garoppolo UNDER 31.5 Passing Attempts (-115)
  • Brandon Aiyuk Anytime TD (+250)

Javonte Williams UNDER 49.5 Rushing Yards (-115)

Javonte Williams is having a strong start to his season, averaging 5.4 yards on 22 carries thus far. With that being said, he and the Broncos now need to face the best run defense in the NFL. The 49ers are allowing only 2.6 yards per carry, which is the best mark in the league through the first two weeks.

Let's bet on him to go UNDER his rushing total tonight.

Jimmy Garoppolo UNDER 31.5 Passing Attempts (-115)

Jimmy Garoppolo averaged 29.4 attempts per game last season, so we already inherently have value on him throwing the ball fewer than 31 times tonight. Let's add in that this will be his first start of the season, so I expect Kyle Shanahan to ease him into the gameplan and rely on the running game throughout.

San Francisco also has the second lowest play percentage this season, calling a pass play just 40.15% of the time.

Brandon Aiyuk Anytime TD (+250)

A lot of rumors were circulating this offseason that Brandon Aiyuk would play a bigger role in the offense this season. He's already received 11 targets this season, hauling in seven catches for 103 yards. I expect that role to grow even more with Jimmy G now under center.

At +250, I think Aiyuk is the best value bet on the board today in terms of anytime touchdown scorers.


You can track Iain's bets on Betstamp here.