49ers vs. Cowboys Updated Odds and Prediction: What Bettors Need to Know for NFC Wild Card Weekend

Jan 9, 2022; Inglewood, California, USA;  San Francisco 49ers wide receiver Deebo Samuel (19) runs for a first down
Jan 9, 2022; Inglewood, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) runs for a first down / Jayne Kamin-Oncea-USA TODAY Sports
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The San Francisco 49ers squeaked into the postseason by coming back to beat the Los Angeles Rams in Week 18. Now, they head to Dallas to face the NFC East champion Cowboys in the NFC Wild Card round.

Has the line moved this weekend? What key injury news are we waiting to hear from the 49ers? We got you covered below, but let's first check out the odds from WynnBET Sportsbook.

49ers vs. Cowboys Odds, Spread and Total

Spread:

  • 49ers: +3 (-105)
  • Cowboys: -3 (-115)

Moneyline:

  • 49ers: +135
  • Cowboys -165

Total: 51 (Over -110/Under -110)

Cowboys vs. 49ers Betting Trends

  • 49ers are 7-2 ATS in their last nine games.
  • The UNDER is 4-1 in the 49ers' last five games.
  • Cowboys are 4-1-1 ATS in their last six games vs. 49ers.
  • Cowboys are 5-1 ATS in their last six games.
  • The UNDER is 8-3 in the Cowboys' last 11 games.
  • Cowboys are 11-1 ATS in their last 12 games vs. NFC opponents.

49ers vs. Cowboys Prediction and Pick

The key news ahead of this weekend is the status of 49ers offensive linemen Trent Williams, who missed Week18 against the Rams, but says that he is on track to play for Sunday.

Williams is massive to a 49ers offense that will look to fend off the Cowboys fearsome pass rush that leads the league in turnover margin.

Here is Iain McMillian's early week thoughts on this matchup.

"The San Francisco 49ers had the top offense in the NFL this season in terms of yards per play, gaining an average of 6.1. The Cowboys are close behind them, ranking third in that statistics averaging 6.0. The big difference between these two teams are their defenses.

The 49ers defense is sixth in opponent yards per play, giving up an average of 5.1, while the Cowboys defense ranks 20th, giving up an average of 5.5. The most important aspect of this game is how effective the San Francisco rushing attack will be against the Dallas defense.

The 49ers run the ball on 47.71% of plays, which is the fourth highest mark in the league. Now they face a Dallas defense that ranks 23rd in opponent yards per carry, giving up an average of 4.5.

The Cowboys roster may be more flashy and sexy, but the playoffs are about being able to play hardnose, ugly football and the 49ers hold a significant advantage in that category. I think San Francisco pulls off the upset in this spot."

Pick: 49ers +130