49ers vs. Rams Updated Odds and Prediction: What Bettors Need to Know

San Francisco 49ers quarterback Trey Lance.
San Francisco 49ers quarterback Trey Lance. / Cary Edmondson-USA TODAY Sports

The San Francisco 49ers and the Los Angeles Rams will finish the season in SoFi Stadium. The Rams are looking to capture a division title while the 49ers are just trying to make the playoffs. The 49ers stomped the Rams in their first meeting 31-10. If they can replicate that, it'll send a message and get San Francisco into the playoffs.

San Francisco has some issues at quarterback, but they are still capable of putting up a fight. Can they pull off the upset they need?

Here are the odds for their matchup via WynnBET.

49ers vs. Rams Updated Spread, Odds and Over/Under


  • 49ers: +4 (-110)
  • Rams: -4 (-110)


  • 49ers: +170
  • Rams: -210


  • 44.5 (Over: -110/Under: -110)

49ers vs. Rams Betting Trends

  • 49ers are 6-2 ATS in their last eight games.
  • The UNDER is 4-1 in the 49ers' last five games.
  • The 49ers are 4-1 ATS in their last five games vs. Rams.
  • Rams are 4-1 ATS in their last five games.
  • The UNDER is 12-3 in the Rams' last 15 home games.

49ers vs. Rams Prediction and Pick

Earlier this week, Iain MacMillan went with the point total as his best bet

I expect the (Rams and Cardinals) to excel in that area in Week 18 as well, as the secondaries for both teams are vulnerable. The Rams defensive strength is stopping the run, but they rank 11th in opponent yards per pass attempt. The 49ers are right behind them, ranking 13th in that stat. ...With that all being said, I'm going to take a shot at this being an offensive shootout. Give me the OVER 44.5.

While the 49ers have been playing well, I don't know if I fully trust the Niner's quarterback situation to get the job done on the road. The Rams are also getting Cam Akers back, and he should provide a small boost on the ground. The 49ers need this win, but the Rams still have seeding to play for and are the better team.

Pick:  Rams -4 (-110)