49ers vs. Rams Updated Prediction and Odds (What Bettors Need to Know)

Los Angeles Rams wide receiver Odell Beckham Jr.
Los Angeles Rams wide receiver Odell Beckham Jr. / Gary A. Vasquez-USA TODAY Sports

The San Francisco 49ers make their second trip to SoFi Stadium this year when they take on the Los Angeles Rams in the NFC Championship game. The 49ers have won both meetings with the Rams this year and are looking for the third to go to the Super Bowl.

Los Angeles is hoping to break whatever curse the 49ers have them under and get back to the Super Bowl for the first time since 2018. The NFC West is guaranteed a spot in the Super Bowl, but who will be the representative?

Here are the odds for their matchup via WynnBET.

49ers vs. Rams Updated Spread, Odds and Over/Under


  • 49ers: +3.5 (-110)
  • Rams: -3.5 (-110)


  • 49ers: +152
  • Rams: -185
  • Total: 46 (Over: -110/Under: -110)

49ers vs. Rams Betting Trends

  • Teams who have won the first two matchups in a single season are 12-6 in third game
  • The Over is 12-3-1 in the NFC Championship Game since 2006
  • The Rams were 4-4 against the spread as a home favorite in 2021.
  • The Rams haven’t hit the OVER in back-to-back games since Weeks 3-4
  • Kyle Shanahan is 2-0 in playoff rematches

49ers vs. Rams Prediction and Pick

When the lines opened on Sunday night, our own Ben Heisler was leaning towards the Rams finally overcoming the 49ers and advancing to the Super Bowl.

Stafford and the Rams are undefeated when he doesn't throw an interception this season. So far in the postseason, he's 2-0, with 568 passing yards, four touchdowns, and no picks. The 49ers matched up perfectly against the Packers and got the perfect break when they needed it. ...I don't see another big break happening again.

I'm fully on board with Ben in this one. The Rams' offense has been clicking over the last two games and I don't see it stopping now. Although the 49ers have won both matchups, they were down 17 for a reason. I don't see the Rams choking away a big lead again. Unless the 49ers' offense can come alive, the Rams should have this in the bag.

Pick:  Rams -3.5 (-110)

 You can find Donnavan Smoot’s full betting record here.