49ers Will Run All Over Chargers' League Worst Run Defense

The San Francisco 49ers will take on the Los Angeles Chargers in a battle of California on Sunday Night Football.

This will be the first time the two teams will face each other since 2018, when the Chargers took home the 29-27 victory. In fact, the Chargers have won the last five meetings between these two clubs. The last time the 49ers beat the Chargers was back on December 3rd, 2000.

Let's dive into the latest odds for tonight's showdown.

Chargers vs. 49ers Odds, Spread, and Total

Chargers vs. 49ers Odds, Spread, and Total Movement

The 49ers opened as 4.5-point favorites. Since then, the line has skyrocketed up four points to 49ers -7.5 Meanwhile, the total has dropped two points from 47.5 to 45.5.

Chargers vs. 49ers Prediction and Pick

It's no secret that the 49ers love to run the football, especially now that they have one of the best weapons in football in Christian McCaffrey. In his latest game, CMC rushed for 94 yards on 18 carries against the Kansas City Chiefs.

He should be drooling at his matchup today. The Chargers have the worst run defense in all of football, ranking dead last in opponent yards per carry, allowing a disgusting 5.7 yards per rush. Unless they drastically fixed their issues since last weekend, the 49ers will be able to run the ball down their throat from start to finish.

It's not just the Chargers defense that has underperformed this season. Many people believed that the Los Angeles offense would be one of the best in the league this year, but they've been average at best. In fact, they've gained only 4.4 yards per play over their last three games, which is the third worst mark in the NFL in the span.

I'll take the 49ers to win big on Sunday night.

You can track Iain's bets on Betstamp here.

Game odds refresh periodically and are subject to change.