Best Monday Night Football Same Game Parlay for Rams vs. 49ers

Same game parlays, particularly on stand-alone prime time games, are a ton of fun. Bettors can still enjoy the intrigue of betting small and winning big if everything comes through, minus the waiting through an entire slate. You can focus in on one matchup and watch as your bets hopefully hit throughout the evening.

At WynnBET, you can build your own same-game parlay with a variety of betting options; ranging from the spread, total, alternatives spreads and totals, and several unique prop bets and promos with multiple outcomes. By using the "Build Your Own Bet" feature, you can move certain lines at adjusted odds to put together a winning ticket.

In this game, the Los Angeles Rams will go on the road to face the San Francisco 49ers and we have a parlay where you can cash in on some favorable odds.

Here is a sample same-game parlay I like for Monday Night Football between the Rams and 49ers. A $25 entry would win $249.16 at +997 odds!

Best Same Game Parlay Picks for Rams vs. 49ers

• Rams -6.5 vs. 49ers (+125)
• Brandon Aiyuk OVER 4.0 Receptions (-125)
• Cooper Kupp OVER 7.5 Receptions (-135)
• Rams-49ers OVER 46.0 Points (-180)

Rams -6.5 vs. 49ers (+125)

Since taking over the Rams in 2017, Sean McVay has been fantastic after a loss, covering the spread in 14 of his 22 games following a defeat. Overall, Los Angeles is 14-7-1 ATS after a loss and 16-6 straight up under McVay after losing.

I think this is a bounce-back spot for the Rams against an overrated 49ers team, and I am willing to move this spread to just under a touchdown because of how potent this offense can be.

Brandon Aiyuk OVER 4.0 Receptions (-125)

Deebo Samuel has been the clear-cut No. 1 option at receiver this season, but the former first-round pick Aiyuk is trending up in the past few games. 

Over his last two contests, Aiyuk has 10 catches on 15 targets and I think he’s in line for a big game with the 49ers possibly facing a negative game script on Monday. I’ll take the over on his catches after he had six in Week 9.

Cooper Kupp OVER 7.5 Receptions (-135)

Robert Woods is out for the year with a torn ACL, but Odell Beckham Jr. is in to take his place. 

What does this mean for Cooper Kupp? At least on Monday, I think it will mean a ton of targets. 

OBJ has only had a few games to get acclimated to the roster, and Van Jefferson is a better option to step up in place of Woods. Kupp is averaging 11.4 targets and 8.2 catches per game this season, hitting the over on this prop number five times. He’s going to do it again Monday. 

Rams-49ers OVER 46.0 Points (-180)

This is a simple pick, as the Rams and 49ers are tied for the second-best over record in the NFL this season at 5-3-1. WynnBET has this total set at 50.0, but I'm going to move the line down to 46.0 to give myself a better chance of it cashing.

Only the Jets (6-3) have hit the over in more game this season than these two teams. There should be plenty of points in Santa Clara on Monday night.