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Best NFL Prop Bets for Giants vs. 49ers on Thursday Night Football

By Iain MacMillan

Sep 17, 2023; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23)
Sep 17, 2023; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23) / Gary A. Vasquez-USA TODAY Sports
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The New York Giants and San Francisco 49ers will meet in the Week 3 edition of Thursday Night Football.

If you want my best bet for every game this week, check out the latest edition of the "Road to 272 Bets".

In this piece, we're talking prop bets. It's the only game for us to watch on Thursday night, so we might as well sprinkle on a few prop bets and have some fun. I have three that I like for the game.

Before I dive into them, let me tell you that if you plan on tailing any of these, you should do so at Caesars Sportsbook. For a limited time, new users will be given up to $1,000 in second chance bets! All you have to do is click the link below to take advantage of this off.

Now, let's dive into some prop bets for Thursday Night Football.

Giants vs. 49ers prop bets

  • Christian McCaffrey OVER 77.5 rushing yards (-135)
  • Daniel Jones OVER 37.5 rushing yards (-129)
  • Nick Bosa OVER 1 sack (+100)

Christian McCaffrey OVER 77.5 rushing yards (-135)

The Giants have struggled to stop the run this season. Heading into Thursday night, they're 25th in the NFL in opponent yards per carry, allowing 4.6 yards per rush. Meanwhile, Christian McCaffrey has already racked up an astounding 268 rushing yards, averaging 6.4 yards per rush.

I'd be shocked if the Giants are able to keep him in check on Thursday. I think he soars past his rushing total of 77.5 yards.

Daniel Jones OVER 37.5 rushing yards (-129)

A big part of the Giants' Week 2 comeback against the Arizona Cardinals, was Daniel Jones' legs. He started to pick up yards on his own, and it led to them completing the improbable victory after being down 20-0.

He already has 102 rushing yards on the season, and with Saquon Barkley now out of the lineup, the Giants by call even more designed quarterback runs.

I'll take the OVER on his rushing total of 37.5.

Nick Bosa OVER 1 sack (+100)

Nick Bosa has had a quiet start to his season. He has only made a combined four tackles and he has yet to record a sack.

I think that changes on Thursday night against a bad Giants offensive line. Daniel Jones has been sacks 10 times already this season, and I'd be shocked if he doesn't get sacked a few more times again on Thursday.

I think Bosa gets on the board with a sack in this one and I love the odds for him to record at least 1.5 sacks at +100.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!

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