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Bills vs. Patriots Updated Odds and Prediction: What Bettors Need to Know

By Donnavan Smoot

New England Patriots quarterback Mac Jones.
New England Patriots quarterback Mac Jones. / Marc Lebryk-USA TODAY Sports
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The New England Patriots and the Buffalo Bills will play for the final time this season with all the marbles on the line. The Patriots are one game up on the Bills in the division, but the Bills could get back on the inside track with a win this week.

This game should look a lot different than the "Wind Bowl" three weeks ago, and will have much higher stakes. Can the Bills get revenge and get back on track?

Here are the odds for their matchup via WynnBET.

Bills vs. Patriots Updated Spread, Odds and Over/Under

Spread: 

  • Bills: +2 (-110)
  • Patriots: -2 (-110)

Moneyline: 

  • Bills: +115
  • Patriots: -135
  • Total: 43.5 (Over: -110/Under: -110)

Bills vs. Patriots Betting Trends

  • The OVER is 4-2 in the Bills last six games.
  • Bills are 3-7 ATS in their last 10 games against Patriots.
  • Bills are 4-1-1 ATS in their last six games vs. AFC East opponents.
  • Patriots are 7-1 ATS in their last eight games.
  • Patriots are 4-1 ATS in their last five games vs. AFC East opponents.

Bills vs. Patriots Prediction and Pick

The Patriots controlled the game the last time these teams met, but Iain MacMillan doesn’t think that will happen again.

The Bills rank 10th in yards per play (5.8) and fourth in points per play (0.429) ahead of their Week 16 game. There's no reason to believe that Josh Allen and company won't be able to find more success in this week's edition of the matchup. Especially considering they torched one of the best pass defenses in the NFL last week in the Panthers.

The Bills rank 10th in yards per play (5.8) and fourth in points per play (0.429) ahead of their Week 16 game. There's no reason to believe that Josh Allen and company won't be able to find more success in this week's edition of the matchup. Especially considering they torched one of the best pass defenses in the NFL last week in the Panthers. ...If Mac Jones is forced to throw the ball, he could run into trouble against a Bills defense that ranks first in the NFL in opponent yards per pass attempt (5.4).

I have jumped off the Bills’ bandwagon and I’m going to stay off this week. Not only are the Patriots at home, but they are also the favorite. In the last 10 years, New England is 67-16 SU as a home favorite. I think that trend continues and they lock up the AFC East.

Pick: Patriots -2 (-110)

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