Chargers vs. Texans Prediction, Odds, Against Spread and Over/Under for NFL Week 16

Los Angeles Chargers quarterback Justin Herbert.
Los Angeles Chargers quarterback Justin Herbert. / Gary A. Vasquez-USA TODAY Sports

The Los Angeles Chargers look to bounce back from their Thursday Night Football loss to the Kansas City Chiefs when they take on the 3-win Houston Texans in Week 16. 

Houston and Davis Mills handled the Jacksonville Jaguars in Week 15, and they get a crack at a potentially short-handed Chargers squad with several key players getting placed on the Reserve/COVID-19 list on Monday. 

Can Justin Herbert and company still stay afloat in the AFC playoff picture? 

Here are the latest odds via WynnBET:

Chargers vs. Texans Odds, Spread and Total


  • Chargers -10.5 (-110)
  • Texans +10.5 (-110)


  • Chargers: -490
  • Texans: +390


  • 47.5 (Over -110/Under -110)

Texans vs. Chargers Betting Trends

  • The Chargers are 7-7 against the spread this season.
  • The Texans are 6-8 against the spread this season.
  • The Chargers are 0-1 against the spread as a road favorite.
  • The Texans are 3-3 against the spread as a home underdog. 
  • The OVER is 7-7 in the Chargers’ 14 games.
  • The UNDER is 8-6 in the Texans’ 14 games. 

Chargers vs. Texans Prediction and Pick

Yes, Houston beat the lowly Jaguars in Week 15, but don’t expect that to continue this week. 

The Texans are just 3-4 against the spread this season as a double-digit underdog, and they’re facing a Chargers offense that has been humming in recent weeks. 

Houston allows the fifth most yards per play in the NFL (5.8) this season, and the Chargers can probably get by offensively as long as Herbert, Mike Williams and Keenan Allen remain in the lineup. 

Davis Mills has shown some flashes this season, but the way you beat the Chargers is on the ground, and the Texans are dead last in the NFL in rushing yards (1,083) and yards per carry (3.2).

This is a great bounce-back spot for the Chargers and I think they win this game convincingly. 

Pick: Chargers -10.5 (-110)