Chiefs vs. Colts Prediction, Odds, Spread and Over/Under for NFL Week 3

Kansas City Chiefs quarterback Patrick Mahomes.
Kansas City Chiefs quarterback Patrick Mahomes. / Jay Biggerstaff-USA TODAY Sports

Patrick Mahomes and the Kansas City Chiefs erased an early 10-0 deficit in Week 2 against the Los Angeles Chargers to remain undefeated early in this season. 

Meanwhile, things are in dire straits for Matt Ryan and the Indianapolis Colts, as they were shut out by the Jacksonville Jaguars in Week 2 to fall to 0-1-1 on the season despite playing Jacksonville and Houston in their first two games. 

Frank Reich’s teams are notorious for slow starts, but now they have to take a step up in class against Mahomes and company, who will have some extra rest as well after playing on Thursday Night Football in Week 2. 

Let’s jump into the odds from FanDuel for this Week 3 matchup: 


Chiefs vs. Colts Odds, Spread and Total

Colts vs. Chiefs Betting Trends

  • The Colts are 0-2 ATS this season
  • The Chiefs are 2-0 ATS this season
  • The UNDER is 2-0 in the Colts’ games this season
  • Frank Reich is 5-10-1 straight up in September as Colts head coach
  • Patrick Mahomes is 13-2 in September in his NFL career

Chiefs vs. Colts Prediction and Pick

So, about Matt Ryan being an upgrade for the Colts at quarterback?

After Carson Wentz torched the Jaguars in Week 1, Ryan struggled mightily against them, throwing for just 195 yards and three interceptions in the team’s shutout loss. 

Yikes. I won’t say that Matty Ice is washed, but he certainly doesn’t look good right now. To make matters worse, the Colts played themselves away from using Jonathan Taylor, despite the fact that he had nine carries for 54 yards. 

Unless Indy goes back to feeding him at volume, it appears that this offense could be stuck in mud under Ryan. Kansas City has also been solid against the run this season, allowing just 3.9 yards per carry. They’ve faced decent running backs too in James Conner and Austin Ekeler through the first two weeks. 

The fact that Trevor Lawrence was able to dice up the Colts is seriously concerning for them against Mahomes, who has been fantastic to start the 2022 season. Plus, Mahomes is elite in September in his career, going 13-2 straight up. 

I love the Chiefs as a moneyline parlay piece, but I’ll also back them to cover against this questionable Colts team. 

Find Peter Dewey’s full betting record here.