Colts vs. 49ers Odds, Spread, Over/Under and Prediction for NFL Week 7

The Colts are set to face the 49ers in NFL Week 7 action.
The Colts are set to face the 49ers in NFL Week 7 action. / Trevor Ruszkowski-USA TODAY Sports

The Indianapolis Colts and San Francisco 49ers will face-off in a game between two teams who have underperformed compared to people’s expectations through the first six weeks of the NFL season.

The Colts were supposed to be a potential contender in the AFC with Carson Wentz under center, and many people believed that the 49ers would be the team to beat in the NFC West. Instead, both teams will enter the game with a losing record. The Colts sit at 2-4 while the 49ers will enter the week with a 2-3 record after their Week 6 BYE.

Let’s take a look at the odds for this inter-conference matchup, courtesy of WynnBET Sportsbook.

Colts vs. 49ers Odds, Spread and Over/Under


  • Colts +4
  • 49ers -4


  • Colts +175
  • 49ers -200


  • 45 (Over -110/Under -110)

Colts vs. 49ers Betting Trends

  • Colts are 4-1 ATS in their last five games.
  • Colts are 5-2 ATS in their last seven games vs. 49ers.
  • The OVER is 5-1 in the Colts last six road games.
  • 49ers are 1-4 ATS in their last five games.
  • 49ers have lost six straight games at home.

Colts vs. 49ers Prediction and Pick

The hardest games to handicap are those between two average teams that don’t have any significant strengths or weaknesses. That’s exactly what we have in this game between the Colts and 49ers.

Indianapolis is slightly better offensively, ninth in yards per play compared to San Francisco at 16th, but the 49ers are slightly better defensively, eighth in opponent yards per play compared to the Colts at 22nd.

Both teams have a balanced attack of both run and pass plays, neither team is particularly better at defending one more than the other. If you’re looking at statistics to help you make your bet in this game, you’re only going to get more confused.

In situations like this, I usually look to the total instead and that’s what I’m going to do. The 49ers are averaging 23.4 points per game and the Colts are averaging 23.2. With the San Francisco defense being underwhelming this year and the Indianapolis defense being nonexistent at times, I’m going to go ahead and back the OVER 45 in this one.

Pick: OVER 45 -110

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