Monday Night Football Best Prop Bets for Rams vs. 49ers

An NFC West Division clash will take place on Monday Night Football, as the Los Angeles Rams go to San Francisco to face the 49ers. 

Los Angeles is a 3.5-point road favorite in this matchup, but I have my eye on some prop bets in this matchup. 

Here are some of my favorites with all odds via WynnBET Sportsbook:

Best Prop Bets for Rams vs. 49ers

• Darrell Henderson Anytime Touchdown Scorer (-150)
• Cooper Kupp OVER 7.5 Receptions (-135)
• Brandon Aiyuk OVER 4.0 Receptions (-125)

Darrell Henderson Anytime Touchdown Scorer (-150)

The 49ers have allowed the third-most rushing touchdowns in the NFL this season (12) behind only the New York Jets and Houston Texans. 

I don’t love laying the -150 juice, but Henderson is clearly the lead back in the Rams’ offense and has already scored seven times this season. He’s coming off a down game last time out and I think this is a great bounce-back opportunity. 

Cooper Kupp OVER 7.5 Receptions (-135)

Robert Woods is out for the year with a torn ACL, but Odell Beckham Jr. is in to take his place. 

What does this mean for Cooper Kupp? At least on Monday, I think it will mean a ton of targets. 

OBJ has only had a few games to get acclimated to the roster, and Van Jefferson is a better option to step up in place of Woods. Kupp is averaging 11.4 targets and 8.2 catches per game this season, hitting the over on this prop number five times. He’s going to do it again Monday. 

Brandon Aiyuk OVER 4.0 Receptions (-125)

Deebo Samuel has been the clear-cut No. 1 option at receiver this season, but the former first-round pick Aiyuk is trending up in the past few games. 

Over his last two contests, Aiyuk has 10 catches on 15 targets and I think he’s in line for a big game with the 49ers possibly facing a negative game script on Monday. I’ll take the over on his catches after he had six in Week 9.