Monday Night Football Best Same Game Parlay Picks for 49ers vs. Cardinals (Go Back to George Kittle in Mexico City)

San Francisco 49ers tight end George Kittle celebrates a touchdown in their victory over the L.A. Rams back in October.
San Francisco 49ers tight end George Kittle celebrates a touchdown in their victory over the L.A. Rams back in October. / Gary A. Vasquez-USA TODAY Sports
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According to ESPN Stats and Info, Arizona Cardinals head coach Kliff Kingsbury is the only head coach in the Super Bowl era to have a winning record as an outright underdog (17-16-1), while also going 11-14 as a favorite.

And yet, the oddsmakers in Vegas don't seem to be all too concerned that tonight's matchup in Mexico City at Estadio Azteca for Monday Night Football will follow that trend when they take on the San Francisco 49ers.

After San Francisco hung around all week anywhere between -8 and -8.5, the line has been on the move throughout the day. Let's take a look at where things currently stand, along with where the odds first opened.

Monday Night Football Odds for 49ers vs. Cardinals in Mexico City

BetSided's put together our favorite bets on the spread, as well as top prop picks and anytime touchdown scorers for tonight's matchup. Now, let's combine forces and bring several top plays into one play with a same game parlay.

Using the odds provided at FanDuel Sportsbook, here is a 5-leg same game parlay (SGP) paying out odds at +630. Therefore, a $25 bet would win $157.67.

Let's go through each of them.

Best Same Game Parlay Picks for 49ers vs. Cardinals on Monday Night Football

Odds via FanDuel Sportsbook

49ers -2.5 (alternate spread) -390

I'm on record of taking the Cardinals at +9, but with the late move this morning towards the 49ers side, I'll admit, I'm a bit nervous of what Vegas may know. Colt McCoy was always expected to be the starter, even with Kyler Murray practicing in a limited capacity this week, but now that it's official, it doesn't appear to be the key reason why the line moved as much as a point and a half.

Instead, I'll move the line down to just the 49ers covering by a field goal in Mexico City. The 49ers should have little issue moving the ball against Arizona's defense, but will need to convert more consistency on third down and also in the red zone to make this the blowout oddsmakers expect.

Kyle Shanahan is just 19-28-1 against the spread as a favorite, and Kliff Kingsbury is 21-11-2 ATS as a dog. Rather than risk it by just taking Arizona, we'll improve our opportunity as part of this parlay and move it to an easy field goal cover for the Niners.

OVER 39.5 (alternate total points) -210

The total currently sits at 43.5, so we'll drop it down to 39.5 to cover past multiple key numbers in 40, 41 and 43. 41 is the much more impactful number, but both of these two teams have already played several games within that 39.5 - 43 range.

Arizona has made some strides with their defense since the beginning of the year, but the over has still hit in four consecutive games, while the over has hit in two of San Francisco's last three.

George Kittle 40+ Receiving Yards -172

If there's a competent tight end on the roster, it's almost an auto-play each week against the Cardinals.

Arizona has allowed the most receiving yards by far to the position, leading by 100 full yards to the second-worst team in the Seattle Seahawks, as well as with 13 more receptions than the Miami Dolphins.

Last week vs. the Chargers, Kittle was only targeted twice by Jimmy G, catching one ball for 21 yards. That's simply not good enough, especially vs. a team in Arizona that has telegraphed opportunities all year long.

Christian McCaffrey 50+ Rushing Yards (alternate total) -245

McCaffrey finished Week 10 with 77 total yards and a touchdown in the victory vs. L.A, but with the oddsmakers expecting a double digit victory in the altitude of Mexico City, I'll grab CMC to go above 49.5 rushing yards in a game script that sets up perfectly for more rushing opportunities than receiving ones.

Via FantasyPros, McCaffrey ranks 13th in evaded tackles and should cruise vs. Arizona's 30th ranked DVOA defense vs. running backs.

James Conner OVER 19.5 Receiving Yards (-110)

For similar reasons why I'm backing McCaffrey's rushing yards, I'll take a very reasonable number to go over on for James Conner on the receiving end.

Conner played nearly all the snaps in their win over the Rams last week, while also catching three targets for 17 yards. While that didn't exceed the total on the board, the Cardinals will need to have him involved heavily in the passing game as they're expected to be playing from behind, perhaps by as much as double digits.

Furthermore, it's much more advantageous to throw the ball, especially to running backs against San Francisco rather than run on them. The Niners are first in football in opponent yards/rush, and second in opponent yards/play.


Game odds refresh periodically and are subject to change.