NFL Week 7 Upset Picks (Lions Shock Cowboys, New York Teams Stay Hot in Top Predictions)

Detroit Lions quarterback Jared Goff.
Detroit Lions quarterback Jared Goff. / Bob DeChiara-USA TODAY Sports

Week 6 was full of upsets in the NFL, and the BetSided team was on the right side of the week, hitting three upset picks!

That moves our record to 13-17 on the season (+5.86 units). With several teams on the bye in Week 7, there are still teams to back to pull off an upset this week. 

Here’s who the team is backing in Week 7: 

Best NFL Upset Picks for Week 6 of 2022 Season

New Orleans Saints (+118) at Arizona Cardinals

For the second consecutive week, a slight home favorite is going down straight up in their own building.

The Cardinals look lifeless offensively right now. Perhaps the spark of DeAndre Hopkins returning makes a noticeable difference, but as he returns, Hollywood Brown is likely down for the season with a foot injury. They've also been one of the worst home teams vs. the spread since Kliff Kingsbury became head coach, and Kyler Murray was drafted; going 10-17 ATS at home.

With unders 16-4 over the last 20 Thursday Night Football games, that offers a little more life on the side of the dog. New Orleans' offense has woken up, even with several injuries, and Alvin Kamara is on the right side of positive touchdown regression facing an Arizona defense ranked 20th in Football Outsiders' Total DVOA.

Murray and Kingsbury don't deserve the benefit of the doubt in a short week at home. Maybe the Saints don't either, but this is a good matchup for them and a great spot to take the dog outright. – Ben Heisler

New York Giants (+140) at Jacksonville Jaguars

Somehow, someway the New York Giants are 5-1 on the 2022 season heading into a matchup with the struggling Jacksonville Jaguars. 

The Jaguars haven’t looked great on offense over the last three weeks, and I question how they’ll handle a Giants defense that ranks 11th in the NFL in yards per play allowed. 

The Jaguars defense ranks 23rd in that same category, and I expect the Giants to be able to gash them with Saquon Barkley all game long. Brian Daboll’s team has put things together early on in this season, and I actually have a lot more confidence in the Giants staying consistent than the Jags getting out of this rut.

Detroit Lions (+265) vs. Dallas Cowboys

I was never a Lions believer heading into the season, refusing to subscribe to the feel good nature of Dan Campbell's coaching style, but this is an incredible spot to get the Lions, who are likely going to welcome Dak Prescott back to the field. 

The Cowboys are coming off wins against the Rams and Eagles where the defense was left on the field often to make up for the lack of vertical passing game from Cooper Rush and are facing off against a refreshed Lions team that just had a much needed bye week after a swarm of injuries across the roster.

The Lions defense leaves a ton to be desired, but with an extra week to prepare and get some key players back to 100% on offense like D'Andre Swift to help keep pace with Dallas. I think Detroit is super live in this matchup to stun Dallas on the road.

Seattle Seahawks (+230) at Los Angeles Chargers

The Chargers escaped a tough game against the Denver Broncos at home, but will they be able to win a shootout against the Seahawks? Seattle’s offense has been carrying it through this season, and it gives the Seahawks a chance this week. Kenneth Walker Jr. will be able to run as much as he wants against the second-worst rushing defense in the league. On top of that, Geno Smith will be able to complete big plays against a secondary that is weak on one side of the field.

All of the Chargers’ wins have been too close for comfort at some point in the fourth quarter. I don’t see them stopping out the Seahawks, and letting them hang around will prove detrimental.

New York Jets (+100) at Denver Broncos

The Jets are HERE, folks! They've covered the spread in four of their last five games with three straight underdog wins as the defense is suddenly one of the NFL's most dominant units. It's seventh in the NFL in opponent yards per play (5.0) with Sauce Gardner and Quinnen Williams forming a stellar duo.

New York's offense isn't half-bad either, averaging the 10th-most points per game (23.8) thanks to Breece Hall's emergence.

You may have heard, but Denver is an unmitigated disaster. The Broncos' defense is good, but Russell Wilson's acquisition already looks like one of the worst trades in modern history. Denver's offense is dead-last in points per game (15.2) and everyone involved looks absolutely miserable.

I don't have a stat for this, but vibes matter. The Jets are riding high, and nearly every member of the Broncos looks like they're desperately calling their agent to get them out of this burning building. Wilson and Nathaniel Hackett have torpedoed any playoff hopes Denver had, and the Jets are primed to land the final knockout punch.

Trust Sauce, trust Hall, and trust New York to pull off a fourth-straight upset.

Indianapolis Colts +125 at Tennessee Titans

I don't care what anyone says, the Titans are a bottom three team in the NFL and shouldn't be favored against almost anyone. They rank dead last in the NFL in net yards per play at -1.4, which is -0.5 worse than the next worst team.

A big reason for their struggles is that they rely on running the ball, with the fifth highest run play rate in the NFL, but yet they stink at doing it. They rank 27th in the NFL in yards per carry, averaging just 3.7 yards per rush. To make matters worse, their defense is second last in the NFL in opponent yards per play, with only the Lions defense giving up more yards.

I know the Titans beat the Colts back in Week 4, but the Colts outgained them 5.8 yards per play to 4.7 yards per play. If it wasn't for Indianapolis coughing up three untimely turnovers, then they would have walked away from that game victorious. I think they get their revenge on the Titans on Sunday. – Iain MacMillan

Game odds refresh periodically and are subject to change.