Oregon vs Ohio State Prediction and Odds for College Football Week 2

Ohio State is set to take on Oregon for the first time since the 2015 College Football National Championship Game.
Ohio State is set to take on Oregon for the first time since the 2015 College Football National Championship Game. / Kyle Robertson/Columbus Dispatch via

If you’re only going to watch one college football game this weekend, make sure it’s the one between Oregon and Ohio State.

In what is one of the best, if not the single best, interconference game of the season, Oregon will try to prove it's a national contender this year when it travels to Ohio Stadium to take on the Buckeyes.

Oregon barely escaped disaster in Week 1, needing a fourth quarter comeback to beat Fresno State.

Ohio State had a scare of its own, as it entered halftime in its game against Minnesota down 14-10, but turned things on in the second half to eventually win the game 45-31.

This will be the first time that these two schools will face each other since the 2015 National Championship Game when the Buckeyes took down the Ducks 42-20.

The two schools have faced each other in football nine times, and Ohio State has won all nine meetings.

Here are the odds for the game, courtesy of WynnBET Sportsbook.

Oregon vs Ohio State Spread, Odds, and Total


Oregon: +14.0 (-105)

Ohio State: -14.0 (+105)


Oregon: +460

Ohio State: -610


63.5 (OVER -110/UNDER -110)

Oregon vs Ohio State Betting Trends

  • Ohio State has covered the spread in its previous two meetings against Oregon.
  • The total has gone UNDER in the previous two meetings between the teams.
  • Ohio State pushed the spread in Week 1, the total went OVER.
  • Oregon did not cover the spread in Week, the total went UNDER.
  • The Buckeyes have won 22-straight games at home.

Oregon vs Ohio State Prediction and Pick

Oregon was supposed to be the cream of the crop this season, but they barely walked away with a win against Fresno State from the Mountain West.

Ohio State also didn’t look great, but they pulled it together in the second half against a Minnesota team that may not be much worse than Oregon.

It’s a shame to see, but the Pac-12 has faded into irrelevancey on the national level over the past decade, and considering Ohio State’s history against the program, I don’t think this is the year that the Ducks get their first win against the Buckeyes.

I’ll take Ohio State to cover the 14-point spread, and I’d recommend jumping on it before it moves to 14.5 or 15.

Want to bet on this highly anticipated interconference matchup? Download the WynnBET app now.