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Panthers vs. Bills Updated Odds and Prediction: What Bettors Need to Know

By Matt De Saro

The Panthers will need DJ Moore on the field in Week 15 to cover the double-digit spread in their game against the Buffalo Bills.
The Panthers will need DJ Moore on the field in Week 15 to cover the double-digit spread in their game against the Buffalo Bills. / Mark J. Rebilas-USA TODAY Sports
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Both the Carolina Panthers and Buffalo Bills enter Week 15 off eye-opening losses but for different reasons. For the Bills, it is becoming very clear that they are the Super Bowl contenders that we all thought they would be. It’s actually laughable to think that just a few weeks ago they were favorites to win it all and Josh Allen was the favorite to win the MVP. Despite this, they showed a lot of grit last weekend and fought back from a 21 point halftime deficit to force overtime in Tampa Bay. They ultimately lost but it was the most life I have seen from this team in a few weeks.

On the flip side, the Panthers lost to a very shaky Atlanta Falcons team led by Matt Ryan. It was the second time in the last few weeks that the Panthers have benched Cam Newton for P.J. Waker. Considering that Newton has only been on the team for a few weeks, this is a major concern. 

With that in mind, let's tear into the updated odds for this Week 15 clash, courtesy of WynnBET Sportsbook.

Panthers vs. Bills, Spread, and Total Odds

Spread:

  • Panthers: +10.5 (-110)
  • Bills: -10.5 (-110)

Moneyline:

  • Panthers: +400 / Opened +425
  • Bills: -500 / Opened -550

Total:

  • 44.5 (Over -110/Under -110) / Opened 43.5

Panthers vs. Bills Betting Trends

  • The Panthers are 5-8 against the spread (ATS) in their last 13 games. 
  • The Panthers are 3-3 ATS in their last six games on the road. 
  • The Panthers are 2-1 ATS as a road underdog this season. 
  • The Panthers are 2-2 ATS in non-conference games this season. 
  • The Bills are 7-6 ATS in their last 13 games. 
  • The Bills are 4-5 ATS in their last nine non-division games. 

Panthers vs. Bills Prediction and Pick

As a fan of Cam Newton, I have to admit that his return to Carolina has been difficult to watch. Aside from his first game where he saw limited action, it's been a pretty brutal homecoming. In fact, it made me remember why the Panthers go rid of him in the first place. 

Early in the week, I didn’t pay much attention to the health of D.J. Moore who is dealing with a hamstring issue. I figured he’d be on the injury report but practice and be ready to rock this weekend. That is becoming less and less of a reality as Moore, who leads the team in receiving yards, was still a limited participant in practice yesterday and today. His status for Sunday remains unknown. 

This gives me a bit more worry for my pick heading into the weekend but I remain confident that the Bills still haven’t worked out all their issues. Without Moore, the Panthers will have more trouble covering this game but at least he has been practicing. As long as he participates tomorrow, I feel good about his ability to contribute on Sunday. I’m still rolling with the Panthers to lose but cover this hefty spread. 

Prediction: Carolina Panthers +10.5 (-110)

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