Rams vs. Cardinals Prediction Updated Odds and Prediction: What Bettors Need to Know

Dec 5, 2021; Chicago, Illinois, USA; Arizona Cardinals quarterback Kyler Murray (1) passes the
Dec 5, 2021; Chicago, Illinois, USA; Arizona Cardinals quarterback Kyler Murray (1) passes the / Quinn Harris-USA TODAY Sports

Monday Night Football pits two NFC West contenders in a game that will possibly decide the the NFC West when the Arizona Cardinals host the Los Angeles Rams.

The Cards are 10-2 on the year, and this is a last effort for Matthew Stafford and the Rams to catch them at as they enter at 8-4.

Let's check out the updated odds from WynnBET Sportsbook for this showdown.

Cardinals vs. Rams Odds, Spread and Total


  • Cardinals: -2 (-110)
  • Rams: +2 (-110)


  • Cardinals: +115
  • Rams: -135

Total: 51 (Over -110/Under -110)

Cardinals vs. Rams Betting Trends

  • Rams are 1-5 ATS in their last six games.
  • Rams are 7-1-1 ATS in their last nine meetings with the Cardinals.
  • Rams are 2-5 ATS in their last seven road games.
  • Cardinals are 8-2 ATS in their last 10 games.
  • Cardinals have the best straight up record in the NFL at 10-2.

Cardinals vs. Rams Prediction and Pick

Our Iain McMillian made the case for the Rams as underdogs earlier in the week, and the betting market agreed with the line moving the line inside of a field goal. Here is his betting breakdown from earlier in the week:

"The Rams hit a slump in their season, losing three straight ugly games, but I'm going to die on the hill of thinking Los Angeles is a serious Super Bowl contender. ...The Rams rank first in the entire NFL in yards per play at 6.2, and their defense ranks fourth in the NFL in opponent yards per play at 5.1. The Cardinals rank 11th (5.7), and sixth (5.2) in those categories, but in their defense, they were without quarterback Kyler Murray for three games this season."

One key thing to note about the Arizona defense, is that it's vulnerable in the run game. It ranks 30th in the league in opponent yards per carry, allowing opposing teams to gain an average of 4.7 yards per rush. You may want to target Darrell Henderson or Sony Michel in fantasy this week. ...The run game is a strength for the Rams, who rank second in opponent yards per carry keeping them to 3.8 yards per rush. ...I'm going to back the statistics in this one, and continue to bet on the Rams."

Pick: Rams +3