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Monday Night Football Best Bets for Rams vs. 49ers (San Francisco's Offense Bounces Back at Home)

By Ben Heisler

San Francisco 49ers wide receiver Deebo Samuel could be in line for a major workload vs. a Rams' defense that's regressed to the mean in 2022.
San Francisco 49ers wide receiver Deebo Samuel could be in line for a major workload vs. a Rams' defense that's regressed to the mean in 2022. / Kyle Terada-USA TODAY Sports
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Kyle Shanahan's San Francsico 49ers had defeated the L.A. Rams six consecutive times in the regular season before L.A. head coach Sean McVay tasted revenge.

The two NFC West rivals met up for a shot to play in Super Bowl LVI at the Rams' home stadium, with L.A. taking down the 49ers 20-17 to win the NFC and take on the Cincinnati Bengals.

Now, both teams look to improve upon their slow starts through the first four games of the season in Santa Clara on Monday Night Football with the 49ers slight home favorites vs. the Rams.

With so many betting options on the board, let's first take a look at the most up-to-date odds for tonight:

Monday Night Football Odds, Spread and Total for Rams vs. 49ers

Our BetSided team has already put out their favorite betting pick against the spread, as well as top prop bets, anytime touchdown plays, same game parlays, and more. Here are our top three favorites all in one spot.

Monday Night Football Best Bets for Rams vs. 49ers

49ers -1.5 (-110)

There's a few conflicting trends at play in this game.

As BetSided's Peter Dewey points out, Kyle Shanahan historically has been awful as a favorite: going 17-26-1, against the spread, and 9-15-1 at Levi's Stadium.

However, Jimmy Garoppolo has always balled out vs. teams above .500; going 18-8 both straight up and ATS with an 18-8 record.

I find it peculiar that the 49ers have remained home favorites after a disastrous performance last week vs. the Denver Broncos; leading me to think there's a bit of a trap on taking the Rams as an underdog away from home this week. L.A.'s offensive line is banged up, and I think we may see multiple turnovers from Stafford and company on the road.

Matthew Stafford OVER 0.5 Interceptions Thrown

In two regular season games vs. the 49ers, Stafford has thrown for four interceptions and four touchdowns. Even in their postseason victory to go to the Super Bowl, Stafford was picked off in that game as well.

The Super Bowl winning quarterback has not looked the same in the early going of 2022. Via Rich Hribar of Sharp Football Analysis, Stafford is the lowest-rated passer on throws that are 15 yards or more downfield; going just 4-14 with two interceptions.

I'm a bit stunned we're getting this number at even money given his history against this team.

Kyle Juszczyk Anytime Touchdown

Our guy Iain MacMillan wrote up "Juice" to get a touchdown as one of his three favorite anytime TD picks of the game, and with odds at +1100, I'm right there with him.

Juszczyk has been a longtime favorite goalline play of Shanahan, and will use him both in running and passing down spots as the team's longtime fullback.

Garoppollo, despite his flaws remains a very effective passer out of play-action, and that's where Juszczyk has been incredibly effective as a receiver throughout his career.

At odds this high, I love the upside of this bet.

Follow all of Ben's betting plays in real-time HERE!

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