NFL Picks: Our Staff's Best Bets for Week 1

The Cardinals have an upset opportunity in Week 1.
The Cardinals have an upset opportunity in Week 1. / Mark J. Rebilas-USA TODAY Sports

Looking for some NFL picks? Our staff at BetSided has you covered with their best bets for Week 1 of the NFL season.

All odds are courtesy of WynnBET Sportsbook. For even more previews, predictions and analysis, check out our NFL homepage, our College Football page, as well as the full video below.

Arizona Cardinals at Tennessee Titans (+3.0) | Total 53.5


I’m going with the Cardinals as underdogs at +130. I’m fading the Titans this year, I think we’re going to see some regression from them in 2021. 

Last year, team’s put up an average of 398.4 yards per game against them. The only teams that were worse in that category were the Houston Texans, Jacksonville Jaguars and Detroit Lions. 

In Week 1 they’re going to be facing this Cardinals offense that might have, you can argue, one of the best receiving corps in the NFL with DeAndre Hopkins, A.J. Green, Christian Kirk and Rondale Moore. I think the Cardinals are going to run away with this one, I think they’re goint score a lot of points. -- Iain MacMillan

San Francisco 49ers at Detroit Lions (+9.0) | Total 46.0

THE PLAY: 49ers -7.5 (-110) -- Line has since moved to 49ers -9.0 (-105)

This is easy money. The 49ers are going to kill Detroit

Detroit is going to be one of the worst teams in the NFL this year, they drafted a bust in Penei Sewell at offensive tackle and Jared Goff is not a good quarterback. 

I’m all in on the Niners this year as well. I think last year was ruined by injuries, everybody’s back this year. I think we’re going to see a very, very deep and fun San Francisco 49ers team out there this week. They’re going to run away with this game. -- Donnavan Smoot

Denver Broncos at New York Giants (+3.0) | Total 41.5

THE PLAY: Broncos -3.0 (-105)

Teddy Bridgewater is the best quarterback in the NFL against the spread as a starter in his career, going 36-14 and I expect him to continue that magic in his Denver Broncos debut. 

The Broncos return Von Miller and Courtland Sutton from injury and added Kyle Fuller, Patrick Surtain II and Ronald Darby to their secondary. The Broncos were bit badly by the injury bug in 2020, but they have the talent on both sides of the ball to make a run if Bridgewater can play well enough this season. 

I also don’t believe in Daniel Jones and a Giants offense that finished with the second-fewest points in the NFL last season, even if Saquon Barkley is back in the lineup. -- Peter Dewey

Seattle Seahawks at Indianapolis Colts (+3.0) | Total 49.0

THE PLAY: Seahawks -2.5 (-120) -- Line has moved to Seattle -3.0 (-110)

I'm going to go with Seattle. This line actually moved six points when the consensus opened Seattle +3.0 on the road at Indianapolis. 

Russell Wilson has an opportunity here to really make a statement. There was a lot of offseason drama with this team. They go to Indianapolis, and the Colts are a bit of a mess. Carson Wentz had some conversations about why he’s not getting the COVID-19 vaccine as well as their All-Pro linebacker Darius Leonard. Quenton Nelson, their outstanding left guard, may not even play. 

I think watching this line move is very intriguing to where I don’t mind having Seattle as the favorites here. Frank Reich is also 0-3 in season openers as the Colts head coach. This just does not set up well for him especially with all sorts of movement and inconsistencies leading into the start of the season. -- Ben Heisler

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