NFL Week 16 Upset Picks: Bills, Bengals, Broncos Among Top Predictions

Bills quarterback Josh Allen.
Bills quarterback Josh Allen. / Jamie Germano / USA TODAY NETWORK
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The positive weeks keep coming in the BetSided's team's upset picks, as we went 2-1 by selecting the Cincinnati Bengals and Pittsburgh Steelers to pick up wins in Week 15.

That has moved the team's overall record to 31-22-1 this season, and there are a couple of AFC matchups that were are looking at that could decide some things in the playoff race in Week 16.

Here’s who we are backing in this week’s slate, with odds via WynnBET Sportsbook:

Buffalo Bills (+110) vs. New England Patriots

Despite the Patriots running all over the Bills in their Week 13 matchup, I'm going to back Buffalo to exact its revenge in Week 16. Now that the weather is expected to be a lot better than their previous matchup, the Patriots will need to do more than just run the football to keep up with the Bills offense.

The Bills rank 10th in yards per play (5.8) and fourth in points per play (0.429) ahead of their Week 16 game. There's no reason to believe that Josh Allen and company won't be able to find more success in this week's edition of the matchup. Especially considering they torched one of the best pass defenses in the NFL last week in the Panthers.

I'll back Buffalo to get the win on the road. – Iain MacMillan

Baltimore Ravens (+120) vs. Cincinnati Bengals

This Ravens’ team is relentless. Despite their two-game losing streak and falling outside the playoff picture, they’re still playing hard and keeping themselves in games they had no business in.

While John Harbaugh’s analytically-driven decisions to be aggressive on fourth down and on two-point conversions have technically “backfired,” it’s also abundantly clear that his players support those decisions and want to be playing for the win, rather than playing not to lose.

With the Bengals blowing out Baltimore the last time these two teams met, I can see why it’s easy to side with Cincinnati. However, since arriving with the Ravens in 2008, Harbaugh thrives in these types of spots as an underdog, going 40-25-3 ATS.

The Ravens were the top team to win the division at the start of the year, and I think they get a huge road win to get them back where they need to be. – Ben Heisler

Denver Broncos (+100) vs. Las Vegas Raiders

The Denver Broncos are going to be without Teddy Bridgewater in Week 16, but I still think they are live to upset the Raiders in Vegas this week. 

Denver has one of the league’s best defenses, and even with Drew Lock under center they may not need many points to get this win. Las Vegas has put up less than 16 points in three straight games without Darren Waller, and their season is hanging in the balance at 7-7. 

Whoever loses this game is essentially out of the playoff picture, and I think Denver’s defense is the best unit in this matchup. – Peter Dewey


NFL Upset Picks to Date:

LAST WEEK: 2-1

SEASON RECORD: 31-22-1