NFL Week 6 Upset Picks: Titans Over Bills, Geno Smith Getting a Win Among This Week's Predictions

Can Geno Smith lead Seattle to an upset win?
Can Geno Smith lead Seattle to an upset win? / Joe Nicholson-USA TODAY Sports

Who’s on upset alert this week in the NFL? 

Last week, our team went 2-3 picking straight up upsets in the NFL, but we’re still 13-7 on the season in these picks. Not bad through five weeks. 

There are eight different home underdogs this week in the NFL, which could make for some upset magic.

Here’s who we are backing in Week 6, with odds via WynnBET Sportsbook:

Seattle Seahawks (+180) at Pittsburgh Steelers

I'm a believer in Geno Smith. I can't believe I just typed that sentence in 2021, but here I am. 

Even more importantly than that is I have zero faith in the Steelers offense and Ben Roethlisberger to be able to keep up with the Seahawks offense.

Seattle might have to roll with Geno, but they still have Tyler Lockett and DK Metcalf out wide. I think they'll be able to do enough to get the job done against an underperforming Steelers team. -- Iain MacMillan

Arizona Cardinals (+125) at Cleveland Browns

I may be the only member of the BetSided team that isn’t going to fade the Cardinals this week, but I’m not as big of a believer in the Browns as many other people are. 

Cleveland’s defense has looked unstoppable against Davis Mills/Tyrod Taylor, Justin Fields and Kirk Cousins, but it’s allowed 80 points in games against Patrick Mahomes and Justin Herbert, losing both games. 

Kyler Murray and the Arizona offense are in the same category, and I think they win this game if it becomes a shootout. The Browns will be able to run the ball on Arizona, but they did against the Chargers last week and still fell short. Give me the Cards to stay undefeated. -- Peter Dewey

Las Vegas Raiders (+165) at Denver Broncos

It’s been a tumultuous week for the Las Vegas Raiders. The Jon Gruden email scandal clearly loomed over the team during its game against the Chicago Bears. Gruden is out and although the stench of his words are still potent, I’m taking the Raiders to regroup on the road against the Broncos. 

Las Vegas still has a great offense and the Broncos need to be on alert. The Broncos have played competent teams in the last two weeks and have come out on the losing side in both weeks. If the Raiders can get Derek Carr into a rhythm early, I expect them to get the win. The Broncos’ strength is their run defense. However, that might not matter since the Raiders run the ball at the 10th-lowest clip in the league. 

Give me Derek Carr to get the Raiders back on track. -- Donnavan Smoot

Tennessee Titans (+195) vs. Buffalo Bills

The Buffalo Bills’ trouncing of the Kansas City Chiefs in prime time was just what the doctor ordered to get the Bills feeling high and mighty about themselves this week.

Granted, it was an impressive win and they did it on the site where they lost the AFC Championship game a season ago, but Buffalo is still beatable. They still have the occasional tendency to lose their edge when you least expect it, like, I don’t know, Week 1 against the pitiful Steelers at home?

Meanwhile, early reports are that Julio Jones will suit up for Tennessee, in what I expect to be his breakout game of the season. The once-hyped up combination of Jones and A.J. Brown has combined for just 22 catches and one single touchdown so far this year. That has to change.

Don’t forget, when these two teams played last year, the Bills were also the talk of the AFC, and ended up getting destroyed in Tennessee 42-16.

Time to zag while the rest of the betting world is zigging! I love the Titans to cover both the five-points and win outright on Monday night. -- Ben Heisler

Jacksonville Jaguars (+160) vs. Miami Dolphins

Sure, Tua Tagovailoa is on his way back, but I can’t get to this number on a neutral field. The Dolphins have lost four straight with a mix of Tua and Jacoby Brissett, and I can’t lay a number over a field goal with them.

The Jaguars offense has actually been solid as Trevor Lawrence has become more and more comfortable with the pro game. The team is third in success rate dating back to Week 3 while Miami is 26th in defensive success rate this season.

There is still a ton of credit for Miami in the market for being a frisky team last season, but this year is quickly becoming a disaster. I think the Jags can get win No. 1 across the pond. -- Reed Wallach

NFL Upset Picks to Date:



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