San Francisco 49ers’ Patrick Willis out & Vernon Davis in vs Rams

Sep 22, 2013; San Francisco, CA, USA; San Francisco 49ers inside linebacker Patrick Willis (52) reacts after making a tackle against the Indianapolis Colts in the third quarter at Candlestick Park. The Colts defeated the 49ers 27-7. Mandatory Credit: Cary Edmondson-USA TODAY Sports /

The San Francisco 49ers need a rebound-win in the worst way after suffering a second-straight loss Sunday, and they now hit the road in a divisional game against the St. Louis Rams.

They’ve already lost one of their top defensive players in Aldon Smith, and no one knows when he’ll return, so they need everyone else to play Thursday night against a Rams team that they were unable to defeat last year.

Two players they can’t afford to be without is All-Pro tight end Vernon Davis and All-Pro middle linebacker Patrick Willis, and both players were being listed as questionable for Thursday’s showdown vs the Rams.

As it turns out, Willis will miss the game while Davis will play.

Vernon Davis is active. Patrick Willis and Nnamdi INACTIVE
— Ann Killion (@annkillion) September 26, 2013

#49ers Patrick Willis, Nnamdi Asomugha are ruled OUT; Vernon Davis is ACTIVE
— Cam Inman (@CamInman) September 26, 2013

Davis is dealing with a hamstring injury and missed the Week Three loss to the Colts, practiced Monday and Tuesday on a limited basis.

Willis has a groin injury and didn’t practice on Monday or Tuesday.