| Saturday, October 19 |
| TIME (ET) | MATCHUP | TV | | | |
| 12:00 PM | No. 11 South Carolina at Tennessee |   | | | |
| 12:00 PM | No. 15 Georgia at Vanderbilt | CBS | | | |
| 12:00 PM | No. 16 Texas Tech at West Virginia | FOX Sports 1 | | | |
| 12:00 PM | TCU at No. 21 Oklahoma State | FOX | | | |
| 12:00 PM | Minnesota at Northwestern |  | | | |
| 12:00 PM | Purdue at Michigan State | BTN | | | |
| 12:00 PM | Southern Miss at East Carolina | | | | |
| 12:00 PM | Southern Methodist at Memphis |  | | | |
| 12:00 PM | Connecticut at Cincinnati |  | | | |
| 12:00 PM | Navy at Toledo |  | | | |
| 12:21 PM | No. 22 Florida at No. 14 Missouri | | | | |
| 12:30 PM | Syracuse at Georgia Tech | | | | |
| 1:00 PM | Akron at Miami (OH) | | | | |
| 1:00 PM | Army at Temple | | | | |
| 1:00 PM | Ohio at Eastern Michigan | | | | |
| 2:00 PM | Charleston Southern at Colorado | | | | |
| 2:00 PM | Ball State at Western Michigan | | | | |
| 2:00 PM | Colorado State at Wyoming | | | | |
| 3:00 PM | No. 23 Northern Illinois at Central Michigan | | | | |
| 3:00 PM | Kent State at South Alabama | | | | |
| 3:30 PM | Iowa at No. 4 Ohio State
Coverage map » |  | | | |
| 3:30 PM | No. 24 Auburn at No. 7 Texas A&M | CBS | | | |
| 3:30 PM | No. 9 UCLA at No. 13 Stanford
Coverage map » | | | | |
| 3:30 PM | No. 18 Oklahoma at Kansas | | | | |
| 3:30 PM | Indiana at Michigan | BTN | | | |
| 3:30 PM | Maryland at Wake Forest | | | | |
| 3:30 PM | Brigham Young at Houston | | | | |
| 3:30 PM | Duke at Virginia | | | | |
| 3:30 PM | Massachusetts at Buffalo | | | | |
| 3:30 PM | North Texas at Louisiana Tech | CBS Sports Network | | | |
| 6:00 PM | No. 20 Washington at Arizona State | Pac-12 Network | | | |
| 7:00 PM | Arkansas at No. 1 Alabama | | | | |
| 7:00 PM | No. 6 LSU at Ole Miss | | | | |
| 7:00 PM | Iowa State at No. 12 Baylor | | | | |
| 7:00 PM | Old Dominion at Pittsburgh | | | | |
| 7:00 PM | Georgia State at Texas State | | | | |
| 7:30 PM | USC at Notre Dame | NBC | | | |
| 8:00 PM | No. 5 Florida State at No. 3 Clemson |  | | | |
| 8:00 PM | No. 25 Wisconsin at Illinois | BTN | | | |
| 8:00 PM | Nevada at Boise State | CBS Sports Network | | | |
| 8:00 PM | Rice at New Mexico State | | | | |
| 9:00 PM | Utah State at New Mexico | | | | |
| 10:00 PM | Washington State at No. 2 Oregon | FOX Sports 1 | | | |
| 10:00 PM | UNLV at No. 17 Fresno State | | | | |
| 10:00 PM | Utah at Arizona | Pac-12 Network | | | |
| 10:30 PM | Oregon State at California | | | | |
