Dec 16, 2012; Houston, TX, USA; Houston Texans defensive end J.J. Watt (99) rushes Indianapolis Colts quarterback Andrew Luck (12) during the third quarter at Reliant Stadium. The Texans won 29-17. Mandatory Credit: Thomas Campbell-USA TODAY Sports

Colts at Texans: odds, prediction and preview

The Indianapolis Colts and Houston Texans are going in completely different directions.

The Colts have built on last year’s surprising playoff appearance, getting off to a 5-2 start, which includes a win over the defending NFC champion San Francisco 49ers and a victory over their former quarterback, Peyton Manning, and the Denver Broncos.

The Colts sit at 5-2 while the Texans at 2-5, are probably the most disappointing team in the NFL.

The Texans have won the AFC South in each of the last two seasons. However, so far this season, the Colts are the only team above .500 in the division.

Colts’s quarterback Andrew Luck will be without veteran wide receiver Reggie Wayne for the first time in his young career. Wayne tore his ACL in the Colts’ victory over the Broncos.

Texans’ quarterback Matt Schuab is once again healthy, but the Texans will go with Case Keenum as the starter for the second consecutive game. Keenum  completed 15-of-25 passes for 271 yards and a touchdown in his first ever NFL action, a 17-16 loss to the Kansas City Chiefs.

The Colts are a three-point favorite and with all of the problems the Texans have had, it would be a surprise if the Colts did not cover.

Kickoff from Reliant Stadium in Houston, Texas is scheduled for 8:30 pm EST Sunday and the game will be on NBC.

Tags: Andrew Luck Houston Texans Indianapolis Colts