NFL Week 5: Picks and predictions

CHARLOTTE, NC - AUGUST 26: Tom Brady #12 of the New England Patriots stays loose on the sideline in the 3rd quarter against the Carolina Panthers at Bank of America Stadium on August 26, 2016 in Charlotte, North Carolina. (Photo by Streeter Lecka/Getty Images)
CHARLOTTE, NC - AUGUST 26: Tom Brady #12 of the New England Patriots stays loose on the sideline in the 3rd quarter against the Carolina Panthers at Bank of America Stadium on August 26, 2016 in Charlotte, North Carolina. (Photo by Streeter Lecka/Getty Images) /
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Sep 25, 2016; Indianapolis, IN, USA; Indianapolis Colts quarterback Andrew Luck (12)drops back to pass during their game against the San Diego Chargers at Lucas Oil Stadium. Mandatory Credit: Thomas J. Russo-USA TODAY Sports
Sep 25, 2016; Indianapolis, IN, USA; Indianapolis Colts quarterback Andrew Luck (12)drops back to pass during their game against the San Diego Chargers at Lucas Oil Stadium. Mandatory Credit: Thomas J. Russo-USA TODAY Sports /

Chicago Bears at Indianapolis Colts (-4.5)

Can Indianapolis (1-3) recover from a tough loss in London without a BYE week to beat Chicago (1-3) and the revamped Brian Hoyer? If the Colts lose this game, at home no less, Chuck Pagano should be canned.

Pick: Indianapolis 31, Chicago 20

New York Jets at Pittsburgh Steelers (-7)

Pittsburgh (3-1) looked insanely good against the Chiefs, and New York (1-3) decidedly did not. Ryan Fitzpatrick is a mess right now, throwing nine interceptions in the last two weeks. Not good.

Pick: Pittsburgh 34, New York 23

Houston Texans at Minnesota Vikings (-6.5)

Minnesota (4-0) is without Teddy Bridgewater and Adrian Peterson, and could care less. Mike Zimmer has his group rolling. Houston (3-1) is a decent team but a faux contender, trumped up by playing in the weak AFC South.

Pick: Minnesota 16, Houston 9

New England Patriots (-10) at Cleveland Browns

New England (3-1) is going to do things to Cleveland (0-4) that North Korea would call excessive.

Pick: New England 45, Cleveland 10

Philadelphia Eagles (-3) at Detroit Lions

Carson Wentz is taking the league by storm in Philadelphia (3-0). On the other hand, we are not sure if Jim Caldwell is still alive in Detroit (1-3). Jim, please blink, we’re scared.

Pick: Philadelphia 27, Detroit 23