2021 NFL schedule release: Picks and predictions for every game

GLENDALE, ARIZONA - AUGUST 20: Quarterback Patrick Mahomes #15 of the Kansas City Chiefs runs up field before the start of the NFL preseason game against the Arizona Cardinals at State Farm Stadium on August 20, 2021 in Glendale, Arizona. The Chiefs defeated the Cardinals 17-10. (Photo by Christian Petersen/Getty Images) /

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PITTSBURGH, PA – DECEMBER 08: T.J. Watt #90 of the Pittsburgh Steelers in action against the Washington Football Team on December 8, 2020 at Heinz Field in Pittsburgh, Pennsylvania. (Photo by Justin K. Aller/Getty Images) /

Week 5

Thursday Night Football

32. 51. 30. 36. Final

Sunday afternoon

Final. 23. 30. 34. 44

35. 35. 52. Final. 33

50. 31. 60. Final. 21

87. Final. 28. 54. 30

Final. 24. 47. 20. 10

56. Final. 31. 49. 19

59. 27. 48. Final. 23

17. 45. 23. 55. Final

21. 31. 24. 123. Final

Final. 21. 57. 23. 28

58. Final. 27. 15. 24

Final. 28. 53. 31. 13

23. 42. 17. 32. Final

Sunday Night Football

Final. 21. 16. 33. 124

Monday Night Football

19. 46. 27. 26. Final

Game of the Week: Bills at Chiefs

A rematch of last year’s AFC Championship Game, and the third matchup of these two teams in the last two campaigns. In 2020, it was the Chiefs winning both games with relative ease. Now, Buffalo comes back with almost the exact same team, trying to dethrone Kansas City.

If the Bills are going to usurp the Chiefs as the top AFC team, it starts with Josh Allen having another top-tier season. Last year, Allen finished as the Second-Team All-Pro quarterback, tied for the honor (with two votes apiece) with Patrick Mahomes. Allen and receiver Stefon Diggs had a special chemistry, with Diggs leading the league in receiving yards.

In Kansas City, much has changed. Out are tackles Eric Fisher and Mitch Schwartz, while general manager Brett Veach has added left tackle Orlando Brown, guards Joe Thuney, Trey Smith and Kyle Long, and centers Creed Humphrey and Austin Blythe. Of course, the main crux of the perennial contender remains the same, with Mahomes, tight end Travis Kelce and receiver Tyreek Hill causing issues for defenses.

A win here for Buffalo would be immense both for confidence and in the standings. Meanwhile, the Chiefs finding a way would further establish them as the clear favorite.

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