DraftKings NFL 2021: Best fantasy football lineup for Week 2

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Sep 12, 2021; Foxborough, Massachusetts, USA; New England Patriots running back Damien Harris (37) gets tackled by Miami Dolphins cornerback Eric Rowe (21) during the second half at Gillette Stadium. Mandatory Credit: Bob DeChiara-USA TODAY Sports /

Flex option: Damien Harris $5,400

The New England Patriots’ backfield is notoriously hard to manage from a fantasy perspective. That’s not the case this year as Harris is clearly the back with the most value. He had 23 carries for 100 yards in the Pats’ Week 1 matchup with the Miami Dolphins and looked efficient and explosive. This Sunday he faces off against a banged-up New York Jets team that is susceptible to the run.

Tight End: Dallas Goedert $4,600

Goedert has officially taken the reigns as the Eagles’ top tight end and was productive in his Week 1 performance against the Atlanta Falcons, corralling four passes for 42 yards and a touchdown. Week 2 brings an enticing matchup against a San Francisco 49ers team that was just torched by Detroit Lions tight end T.J. Hockenson in Week 1. Goedert should continue to produce as one of quarterback Jalen Hurts’ go-to weapons.

Other options: T.J. Hockenson $5,500, Noah Fant $4,200

Defense: Denver Broncos $3,800

The Broncos defense proved in Week 1 that they are still an elite unit capable of shutting down offenses and creating turnovers. Week 2 brings a lopsided matchup with a Jacksonville Jaguars team led by a rookie quarterback in Trevor Lawrence who was intercepted three times by a below-average Houston Texans defense in Week 1. There is a good chance there will be more turnovers from Lawrence and the Jaguars this Sunday against the Broncos.