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5 best fantasy football matchups to exploit for Week 5

By Frankie Licausi

Oct 3, 2021; Orchard Park, New York, USA; Buffalo Bills tight end Dawson Knox (88) gestures to the crowd after a touchdown catch against the Houston Texans during the second half at Highmark Stadium. Mandatory Credit: Rich Barnes-USA TODAY Sports
Oct 3, 2021; Orchard Park, New York, USA; Buffalo Bills tight end Dawson Knox (88) gestures to the crowd after a touchdown catch against the Houston Texans during the second half at Highmark Stadium. Mandatory Credit: Rich Barnes-USA TODAY Sports /
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Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) runs after a catch as Seattle Seahawks cornerback Ugo Amadi (28) attempts a tackle during the fourth quarter at Levi’s Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports
Oct 3, 2021; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) runs after a catch as Seattle Seahawks cornerback Ugo Amadi (28) attempts a tackle during the fourth quarter at Levi’s Stadium. Mandatory Credit: Darren Yamashita-USA TODAY Sports /

2. WR Deebo Samuel vs. the Arizona Cardinals

There’s a new number one receiving option in San Francisco, and his name isn’t George Kittle. It’s Deebo Samuel, who has caught 28-of-42 catches for a league leading 490 yards, while adding three touchdowns. He’s finally healthy and showing the NFL just how dangerous he is.

Jimmy Garoppolo suffered a calf injury in Week 4 against the Seahawks, so his Week 5 status is up in the air. It didn’t seem to matter though, as Samuel caught a 76-yard touchdown from Trey Lance later in the game.

The 49ers are going to have to throw relentlessly to keep up with what is looking like the best offense in the NFL in the Arizona Cardinals. This will lead to plenty of looks, catches, and likely touchdowns in this contest. He will flirt with top-five wideout numbers this week.

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