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NFL Week 6 2021: Picks and predictions for each game

By Matt Verderame

Sep 13, 2021; Paradise, Nevada, USA; Baltimore Ravens quarterback Lamar Jackson (8) against the Las Vegas Raiders during Monday Night Football at Allegiant Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports
Sep 13, 2021; Paradise, Nevada, USA; Baltimore Ravens quarterback Lamar Jackson (8) against the Las Vegas Raiders during Monday Night Football at Allegiant Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports /
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NASHVILLE, TENNESSEE – SEPTEMBER 12: Kyler Murray #1 of the Arizona Cardinals carries the ball during the game against the Tennessee Titans at Nissan Stadium on September 12, 2021 in Nashville, Tennessee. (Photo by Wesley Hitt/Getty Images)
NASHVILLE, TENNESSEE – SEPTEMBER 12: Kyler Murray #1 of the Arizona Cardinals carries the ball during the game against the Tennessee Titans at Nissan Stadium on September 12, 2021 in Nashville, Tennessee. (Photo by Wesley Hitt/Getty Images) /

4:05 p.m. ET. 5-0. 32. FOX. Sunday, Oct. 17. 3-2. 53. CLE -2.5

Also a contender for the best game of the week. Arizona is getting no respect despite being undefeated, coming to Cleveland as an underdog. Expect a ton of points, and the better quarterback to pull the win out late.

Pick: Arizona 33, Cleveland 31

123. Sunday, Oct. 17. 47. DAL -3.5. 4-1. 4:25 p.m. ET. FOX. 2-3

Dak Prescott is playing the best football of his career on a really good Dallas team. Meanwhile, the Patriots needed a miracle — and Houston punting a ball off its own teammate — to beat the Texans.

Pick: Dallas 30, New England 20

28. CBS. 45. 4:25 p.m. ET. 3-2. Sunday, Oct. 17. 3-2. DEN -3.5

This is a brutal spot for the Raiders, who fired their head coach on Monday after heinous emails from Jon Gruden surfaced in an investigation. Tough to see Las Vegas coming out with a ton of fight against a desperate Broncos team.

Pick: Denver 25, Las Vegas 16

36. 55. 2-3. NBC. Sunday, Oct. 17. 2-3. PIT -4.5. 8:20 p.m. ET

If you love great quarterback play, turn off the TV, unplug it and throw it onto the street.

Pick: Pittsburgh 24, Seattle 19

35. 8:15 p.m. ET. ESPN. Monday, Oct. 18. 3-2. BUF -5. 4-1. 16

The Bills might have a bit of a letdown after such an emotional win over the Chiefs, but can the Titans stop them at all? Seems like a fun game with the better team prevailing.

Pick: Buffalo 33, Tennessee 29

Last Week: 11-5
Season: 49-31

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