Fansided

5 best fantasy football matchups to exploit for Week 10

By Frankie Licausi

Oct 17, 2021; Pittsburgh, Pennsylvania, USA; Pittsburgh Steelers running back Najee Harris (22) is stopped by Seattle Seahawks defensive end Darrell Taylor (52) during the second quarter at Heinz Field. Mandatory Credit: Philip G. Pavely-USA TODAY Sports
Oct 17, 2021; Pittsburgh, Pennsylvania, USA; Pittsburgh Steelers running back Najee Harris (22) is stopped by Seattle Seahawks defensive end Darrell Taylor (52) during the second quarter at Heinz Field. Mandatory Credit: Philip G. Pavely-USA TODAY Sports /
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Nov 7, 2021; Baltimore, Maryland, USA; Minnesota Vikings running back Dalvin Cook (33) rushes behind the offensive line during the second half against the Baltimore Ravens at M&T Bank Stadium. Mandatory Credit: Tommy Gilligan-USA TODAY Sports
Nov 7, 2021; Baltimore, Maryland, USA; Minnesota Vikings running back Dalvin Cook (33) rushes behind the offensive line during the second half against the Baltimore Ravens at M&T Bank Stadium. Mandatory Credit: Tommy Gilligan-USA TODAY Sports /

1. RB Dalvin Cook, Vikings (vs. Los Angeles Chargers)

Dalvin Cook going up against the 32nd-ranked Los Angeles Chargers run defense? Forget about it. Cook has a good shot at being the overall top running back in fantasy football this week as he’s playing against the Chargers, who allow 161.6 rushing yards per game.

Cook has 115 carries for 554 yards and two touchdowns, and even with missing a game and having a bye week, he still should compete with Jonathan Taylor for the top running back spot now that Derrick Henry suffered an injury.

This week should help catapult Cook into the top of the running back standings, as he has as good of a chance as any back to score the most fantasy points this week. Consider him a top-five lock with the upside for this week’s fantasy running back crown.