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DraftKings NFL 2021: Best lineup for Week 16

By Frankie Licausi

Cincinnati Bengals quarterback Joe Burrow (9) throws a pass as Denver Broncos defensive end Shelby Harris (96) pressures him in the first half of the NFL football game between the Bengals and the Broncos on Sunday, Dec. 19, 2021, at Empower Field in Denver.Cincinnati Bengals At Denver Broncos 373
Cincinnati Bengals quarterback Joe Burrow (9) throws a pass as Denver Broncos defensive end Shelby Harris (96) pressures him in the first half of the NFL football game between the Bengals and the Broncos on Sunday, Dec. 19, 2021, at Empower Field in Denver.Cincinnati Bengals At Denver Broncos 373 /
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Dec 12, 2021; Green Bay, Wisconsin, USA; Chicago Bears running back David Montgomery (32) during the game against the Green Bay Packers at Lambeau Field. Mandatory Credit: Jeff Hanisch-USA TODAY Sports
Dec 12, 2021; Green Bay, Wisconsin, USA; Chicago Bears running back David Montgomery (32) during the game against the Green Bay Packers at Lambeau Field. Mandatory Credit: Jeff Hanisch-USA TODAY Sports /

Tight End: James O’Shaughnessy, Jacksonville Jaguars ($3,200)

James O’Shaughnessy had easily the best game of his season last week, catching all four of his targets for 60 yards. His volume has been on the increase since the injury to Dan Arnold, and he’s now seen an average of 5.3 targets per game in his last four games.

O’Shaughnessy gets a solid matchup against the Jets, who allow the seventh-most fantasy points to tight ends this season. He’s a solid bargain for us.

Flex: David Montgomery, Chicago Bears ($5,700)

David Montgomery has been a steady RB2 in fantasy since returning from his knee injury, but he gets a huge boost in matchup this week when he takes on the Seattle Seahawks who allow the sixth-most fantasy points to running backs and seemingly give up big days to running backs nearly every week.

Montgomery finishes off what is an impressive three-headed monster in Ekeler, Robinson, and Montgomery. He’s a solid play this week with top-15 upside.

D/ST: Detroit Lions ($2,600)

Picking the Detroit Lions defense in fantasy football sounds crazy, but they dominated Arizona’s explosive offense last week in an impressive victory. They are red hot and coming into a game with the Atlanta Falcons, who can easily be dominated by stronger defenses.

The Lions defense has potential to turn over Matt Ryan a couple times and put tons of pressure on him. They’re a cheap and interesting flier this week.