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NFL Week 2 2022: Picks and predictions for every game

By Matt Verderame

SEATTLE, WASHINGTON - OCTOBER 25: Jameis Winston #2 of the New Orleans Saints looks on against the Seattle Seahawks during the fourth quarter at Lumen Field on October 25, 2021 in Seattle, Washington. (Photo by Steph Chambers/Getty Images)
SEATTLE, WASHINGTON - OCTOBER 25: Jameis Winston #2 of the New Orleans Saints looks on against the Seattle Seahawks during the fourth quarter at Lumen Field on October 25, 2021 in Seattle, Washington. (Photo by Steph Chambers/Getty Images) /
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INGLEWOOD, CALIFORNIA – SEPTEMBER 08: Quarterback Matthew Stafford #9 of the Los Angeles Rams watches from the sidelines during the fourth quarter of the NFL game against the Buffalo Bills at SoFi Stadium on September 08, 2022 in Inglewood, California. (Photo by Kevork Djansezian/Getty Images)
INGLEWOOD, CALIFORNIA – SEPTEMBER 08: Quarterback Matthew Stafford #9 of the Los Angeles Rams watches from the sidelines during the fourth quarter of the NFL game against the Buffalo Bills at SoFi Stadium on September 08, 2022 in Inglewood, California. (Photo by Kevork Djansezian/Getty Images) /

51. LAR -10.5. 0-1. 44. Sunday, Sept. 18. 0-1. FOX. 4:05 p.m. ET

If the Rams struggle here, it’s a huge red flag. Atlanta played New Orleans tough on Sunday, but it shouldn’t be a match for a Los Angeles team on a long break.

Pick: Los Angeles 34, Atlanta 20

FOX. Sunday, Sept. 18. 0-1. SF -10. 4:05 p.m. ET. 1-0. 36. 42

Can Geno Smith outplay Trey Lance? It feels like Seattle had some magic on Monday night, but the Seahawks will bring confidence to the west coast. Expect a tough game.

Pick: San Francisco 21, Seattle 16

0-1. CIN -7.5. 4:25 p.m. ET. 56. CBS. Sunday, Sept. 18. 0-1. 123

Cooper Rush isn’t beating Joe Burrow. If he does, Cincinnati has major problems.

Pick: Cincinnati 23, Dallas 17

0-0-1. DEN -10. 10. CBS. Sunday, Sept. 18. 0-1. 45. 4:25 p.m. ET

Let’s ride? The Broncos were underwhelming — to be kind — against the Seahawks on Monday. Now a home opener against another lackluster opponent. Expect Denver to bounce back.

Pick: Denver 30, Houston 21

Sunday, Sept. 18. 28. 4:25 p.m. ET. LV -6. 0-1. 32. CBS. 0-1

The offenses should both score plenty, but the Raiders are a better team, at home, with Derek Carr attempting to bounce back after three interceptions against the Chargers.

Pick: Las Vegas 33, Arizona 28

1-0. 57. 8:20 p.m. ET. 49. GB -10. NBC. Sunday, Sept. 18. 0-1

This should be where the Packers show their mettle, handle the overwhelmed Bears and run away with a victory at home. That doesn’t happen, Green Bay has serious issues.

Pick: Green Bay 27, Chicago 10

16. 0-1. 35. ESPN. Monday, Sept. 19. 1-0. BUF -10. 6:15 p.m. ET

Tough to see a path for the Titans here. Tennessee can’t match up with Buffalo on either side of the ball. Josh Allen could have another monster day in primetime.

Pick: Buffalo 31, Tennessee 14

ABC. 1-0. PHI -2.5. 7:30 p.m. ET. 60. Monday, Sept. 19. 54. 1-0

Terrific contest to end the week. Whoever wins is going to be seen as a legit contender in the NFC. Philadelphia and Minnesota are very evenly matched, so take the home squad.

Pick: Philadelphia 27, Minnesota 24

Last Week: 7-8-1
Season: 7-8-1

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