DraftKings NFL 2022: Best daily fantasy lineup for Week 6

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Oct 6, 2022; Denver, Colorado, USA; Denver Broncos running back Melvin Gordon III (25) runs the ball as Indianapolis Colts linebacker Bobby Okereke (58) defends in the third quarter at Empower Field at Mile High. Mandatory Credit: Isaiah J. Downing-USA TODAY Sports /

RB1: Melvin Gordon, Denver Broncos ($6,400)

Melvin Gordon looked like the obvious starter for the Denver Broncos last week, leading the Denver backfield in snaps, touches, and yards. He ended up with a pretty decent fantasy day as well, finishing as a top-25 back.

This week, Gordon gets a dream matchup against the Los Angeles Chargers’ 25th-ranked run defense who just got gashed up and down by both Cleveland backs. If Gordon can maintain a stranglehold on Denver’s backfield, he should be a borderline elite option for our lineup.

RB2: Rhamondre Stevenson, New England Patriots ($6,000)

Rhamondre Stevenson was already very slowly taking over New England’s backfield. Now, with Damien Harris nursing a hamstring injury, the path to elite fantasy production is wide open and right in front of Stevenson. He answered the call with a 25-161 game last week.

Stevenson takes on Cleveland, who has been a bottom-five worst run defense in the NFL. A good matchup combined with hopefully elite usage makes Stevenson a strong option who will likely outperform what he costs in DraftKings.