NFL Week 5 2021: Picks and predictions for every game

KANSAS CITY, MISSOURI - JANUARY 24: Patrick Mahomes #15 of the Kansas City Chiefs scrambles with the ball in the first quarter against the Buffalo Bills during the AFC Championship game at Arrowhead Stadium on January 24, 2021 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)
KANSAS CITY, MISSOURI - JANUARY 24: Patrick Mahomes #15 of the Kansas City Chiefs scrambles with the ball in the first quarter against the Buffalo Bills during the AFC Championship game at Arrowhead Stadium on January 24, 2021 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images) /
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Oct 4, 2021; Inglewood, California, USA;Los Angeles Chargers quarterback Justin Herbert (10) drops back to pass against the Las Vegas Raiders during the first quarter at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports
Oct 4, 2021; Inglewood, California, USA;Los Angeles Chargers quarterback Justin Herbert (10) drops back to pass against the Las Vegas Raiders during the first quarter at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports /

53. Sunday, Oct. 10. 3-1. CBS. 3-1. 13. LAC -1.5. 4:05 p.m. ET

Really good game. The Browns should run at will, but Baker Mayfield hasn’t played well at all. Can he step up against Justin Herbert and Co.? Tall order. Possible, but tall.

Pick: Los Angeles 27, Cleveland 24

3-1. LV -5. 2-2. 57. CBS. Sunday, Oct. 10. 28. 4:05 p.m. ET

Justin Fields has finally been put in the starting seat, but that might not be enough here. The Raiders on a short week, but Las Vegas is trying to rebound at home and is the better team.

Pick: Las Vegas 28, Chicago 22

2-2. Sunday, Oct. 10. 4-0. 4:25 p.m. ET. 42. FOX. 32. AZ -5.5

Can the Cardinals stay unbeaten? This is a tricky game, but the uncertainty at quarterback for San Francisco is a problem, along with a beat-up roster in general.

Pick: Arizona 30, San Francisco 28

Sunday, Oct. 10. 3-1. 123. 4:25 p.m. ET. 1-3. 31. FOX. DAL -7

The Cowboys likely win, but don’t sleep on the Giants. New York has kept every game close and finally won last week.

Pick: Dallas 31, New York 27

16. Sunday, Oct. 10. 124. NBC. 2-2. KC -3. 8:20 p.m. ET. 3-1

This is the week’s best game and could go in a litany of directions. However, the Chiefs have been hearing all week how vulnerable they are. Dangerous to doubt a team this accomplished and this good.

Pick: Kansas City 34, Buffalo 29

BAL -6.5. 1-3. 46. Monday, Oct. 11. 3-1. 26. 8:15 p.m. ET. ESPN

The Ravens typically beat up on bad teams, and right now, that’s exactly what the Colts are.

Pick: Baltimore 29, Indianapolis 21

Last Week: 9-7
Season: 38-26