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NFL Week 5 2021: Picks and predictions for every game

By Matt Verderame

KANSAS CITY, MISSOURI - JANUARY 24: Patrick Mahomes #15 of the Kansas City Chiefs scrambles with the ball in the first quarter against the Buffalo Bills during the AFC Championship game at Arrowhead Stadium on January 24, 2021 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)
KANSAS CITY, MISSOURI - JANUARY 24: Patrick Mahomes #15 of the Kansas City Chiefs scrambles with the ball in the first quarter against the Buffalo Bills during the AFC Championship game at Arrowhead Stadium on January 24, 2021 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images) /
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INGLEWOOD, CALIFORNIA – OCTOBER 03: Matthew Stafford #9 of the Los Angeles Rams at SoFi Stadium on October 03, 2021 in Inglewood, California. (Photo by Ronald Martinez/Getty Images)
INGLEWOOD, CALIFORNIA – OCTOBER 03: Matthew Stafford #9 of the Los Angeles Rams at SoFi Stadium on October 03, 2021 in Inglewood, California. (Photo by Ronald Martinez/Getty Images) /

It’s time for the NFL Week 5 picks, and the primetime slate is phenomenal with the Seattle Seahawks and Kansas City Chiefs hosting key tilts.

As always, the lines come from our great partners at WynnBet.

NFLN. 36. 8:20 p.m. ET. 3-1. 51. Thursday, Oct. 7. 2-2. LAR -2.5

The Seahawks need the win, and they’re at home on a short week. Also, quietly, the Rams defense has been giving up a ton of yards. Expect a shootout, and give me the better quarterback.

Pick: Seattle 30, Los Angeles 28

1-3. Sunday, Oct. 10. ATL -3. 8:30 a.m. ET. 30. NFLN. 1-3. 44

England wouldn’t be wrong to declare war on us over this. Just a heinous move by the United States.

Pick: Atlanta 26, New York 20

GB -3.5. 3-1. 3-1. 56. Sunday, Oct. 10. 1 p.m. ET. 49. FOX

Really intriguing matchup. If the Bengals win, we need to start taking them very seriously. If the Packers win, they get a quality road win and keep pulling away in the NFC North.

Pick: Green Bay 31, Cincinnati 26

0-4. TEN -4.5. 35. CBS. 1 p.m. ET. 2-2. Sunday, Oct. 10. 52

If the Titans lose to the Jets and Jaguars in consecutive weeks, it’s over. There’s no other argument to be heard.

Pick: Tennessee 30, Jacksonville 21

1 p.m. ET. 3-1. Sunday, Oct. 10. 1-3. 55. PIT -1. 45. FOX

Offense is going to die a brutal death in this one. These two teams are evenly matched, and the Steelers are both home and very desperate.

Pick: Pittsburgh 18, Denver 15

CBS. 3-1. 48. 1 p.m. ET. 1-3. 59. Sunday, Oct. 10. TB -10

How do the Dolphins win this game? What’s the path? Unless the Buccaneers hand the game to Miami, it seems like the slam dunk of the week.

Pick: Buccaneers 29, Miami 18

2-2. 58. NO -1.5. 1 p.m. ET. 15. CBS. Sunday, Oct. 10. 2-2

This is the complete opposite of the game above. Any outcome could happen. However, the Saints are having all sorts of issues moving the ball, and Taylor Heinicke appears better than Jameis Winston.

Pick: Washington 27, New Orleans 24

50. 1-3. 0-4. FOX. Sunday, Oct. 10. 60. MIN -8.5. 1 p.m. ET

If the Vikings can’t beat the winless Lions, it’s time to start cleaning house before the trade deadline on Nov. 2. This is the epitome of a must-win.

Pick: Minnesota 33, Detroit 20

1 p.m. ET. 1-3. CBS. 1-3. NE -9.5. 10. 47. Sunday, Oct. 10

Bill Belichick is coaching against David Culley and Davis Mills. Just read that sentence again.

Pick: New England 28, Houston 6

1-3. 54. FOX. Sunday, Oct. 10. 1 p.m. ET. 3-1. 87. CAR -3.5

Carolina is a good team which now gets Stephon Gilmore in a few weeks to bolster its secondary. The Eagles aren’t an easy win, but the Panthers should handle business at home.

Pick: Carolina 26, Philadelphia 23

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