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DraftKings NFL 2021: Best lineup for Week 6

By Frankie Licausi

Oct 10, 2021; Inglewood, California, USA; Los Angeles Chargers quarterback Justin Herbert (10) throws against the Cleveland Browns during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports
Oct 10, 2021; Inglewood, California, USA; Los Angeles Chargers quarterback Justin Herbert (10) throws against the Cleveland Browns during the first half at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-USA TODAY Sports /
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Cincinnati Bengals running back Joe Mixon (28) celebrates after scoring a touchdown in the second half of the NFL football game on Sunday, Oct. 10, 2021, at Paul Brown Stadium in Cincinnati. Green Bay Packers defeated Cincinnati Bengals 25-22 in overtime.Green Bay Packers At Cincinnati Bengals 75
Cincinnati Bengals running back Joe Mixon (28) celebrates after scoring a touchdown in the second half of the NFL football game on Sunday, Oct. 10, 2021, at Paul Brown Stadium in Cincinnati. Green Bay Packers defeated Cincinnati Bengals 25-22 in overtime.Green Bay Packers At Cincinnati Bengals 75 /

Running Back 1: Joe Mixon ($6,400)

Joe Mixon played extremely hobbled last week, yet still managed to find the end zone. This week, a full week of practice should bode well for his potential workload against a 23rd-ranked Detroit Lions run defense.

Mixon has mouthwatering upside should he resume his full workload duties this week, as the Lions get gashed against running backs. He’s a little cheaper than the top-tier backs this week but has the potential to finish near the top five.

Running Back 2: Darrell Henderson ($6,000)

Our second back is another one with a great matchup. Darrell Henderson faces a 27th-ranked New York Giants run defense. Even with Sony Michel involved last week, Henderson ran 17 times for 82 yards and a touchdown. It’s clear that the Rams still view him as their starter.

Henderson is seemingly always a bargain as he doesn’t have the elite pedigree as the other backs  do, which is great for us — getting an RB1 for cheap.