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NFL Week 4 2022: Picks and predictions for every game

By Matt Verderame

KANSAS CITY, MO - JANUARY 30: Patrick Mahomes #15 of the Kansas City Chiefs runs with the football during the first quarter of the AFC Championship Game against the Cincinnati Bengals at Arrowhead Stadium on January 30, 2022 in Kansas City, Missouri, United States. (Photo by David Eulitt/Getty Images)
KANSAS CITY, MO - JANUARY 30: Patrick Mahomes #15 of the Kansas City Chiefs runs with the football during the first quarter of the AFC Championship Game against the Cincinnati Bengals at Arrowhead Stadium on January 30, 2022 in Kansas City, Missouri, United States. (Photo by David Eulitt/Getty Images) /
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GLENDALE, ARIZONA – SEPTEMBER 25: Kyler Murray #1 of the Arizona Cardinals is sacked by Terrell Lewis #52 of the Los Angeles Rams during the first half of a game at State Farm Stadium on September 25, 2022 in Glendale, Arizona. (Photo by Michael Owens/Getty Images)
GLENDALE, ARIZONA – SEPTEMBER 25: Kyler Murray #1 of the Arizona Cardinals is sacked by Terrell Lewis #52 of the Los Angeles Rams during the first half of a game at State Farm Stadium on September 25, 2022 in Glendale, Arizona. (Photo by Michael Owens/Getty Images) /

32. 1-2. 87. 4:05 p.m. ET. 1-2. FOX. Sunday, Oct. 2. CAR -1.5

Who to take in this one? Arizona has been a mess in 10 of the 12 quarters it’s played. The Panthers can’t get anything out of Baker Mayfield. Ultimately, give me the better quarterback.

Pick: Arizona 24, Carolina 23

49. GB -9.5. 47. Sunday, Oct. 2. 2-1. 1-2. CBS. 4:25 p.m. ET

If the Packers lose this game, it would be the biggest stunner of the week. The Patriots likely have a backup quarterback, and the roster is without a real playmaker.

Pick: Green Bay 32, New England 20

LV -2.5. 4:25 p.m. ET. 2-1. 45. Sunday, Oct. 2. 28. CBS. 0-3

This is Last Chance Saloon time for the Raiders. The Broncos have two wins, but they’ve looked pathetic offensively. Give me a desperate home team with the better offense, but barely.

Pick: Las Vegas 19, Denver 15

124. Sunday, Oct. 2. 8:20 p.m. ET. 2-1. NBC. 2-1. 48. KC -2

Hard game to handicap. Both teams have all-time quarterbacks (to differing extents) coming off losses. The Chiefs are healthier, but the Bucs might have the more talented roster. Ultimately, Tampa Bay’s pass rush is the difference.

Pick: Tampa Bay 23, Kansas City 20

Monday, Oct. 3. 51. ESPN. 42. SF -2.5. 8:15 p.m. ET. 2-1. 1-2

The Rams always struggle with the Niners, and it happens again. San Francisco will relentlessly pressure Matthew Stafford, and Jimmy Garoppolo can’t be any worse than he was a week ago.

Pick: San Francisco 27, Los Angeles 21

Last Week: 9-7
Season: 25-22-1

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