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NFL Week 4 2022: Picks and predictions for every game

By Matt Verderame

KANSAS CITY, MO - JANUARY 30: Patrick Mahomes #15 of the Kansas City Chiefs runs with the football during the first quarter of the AFC Championship Game against the Cincinnati Bengals at Arrowhead Stadium on January 30, 2022 in Kansas City, Missouri, United States. (Photo by David Eulitt/Getty Images)
KANSAS CITY, MO - JANUARY 30: Patrick Mahomes #15 of the Kansas City Chiefs runs with the football during the first quarter of the AFC Championship Game against the Cincinnati Bengals at Arrowhead Stadium on January 30, 2022 in Kansas City, Missouri, United States. (Photo by David Eulitt/Getty Images) /
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The 2022 NFL regular season is nearing the quarter pole, and we’re starting to see who is good, and who is in for a long year.

As always, all odds are courtesy of our partners at WynnBet.

59. 56. CIN -4. 8:15 p.m. ET. 3-0. AMAZON. Thursday, Sept. 29. 1-2

Tough call, and a great game. Don’t want to underestimate the Dolphins, but the Bengals are home, desperate and healthier. Should come down to the wire, though.

Pick: Cincinnati 31, Miami 28

8:30 a.m. ET. Sunday, Oct. 2. 1-2. 60. NFLN. 15. MIN -3. 2-1

London is calling, and the Vikings are hoping to get off to a 3-1 start. The Saints continue to downplay Jameis Winston’s back injury, but he hasn’t looked sharp the past two weeks.

Pick: Minnesota 23, New Orleans 20

53. CBS. Sunday, Oct. 2. 1 p.m. ET. 2-1. 1-2. 44. CLE -1.5

The Falcons are exceeding my expectations, but the Browns are handling business and should be 3-0. Jacoby Brissett needs to simply hand off, make a few throws to Amari Cooper and get out of the way.

Pick: Cleveland 24, Atlanta 21

FOX. 123. DAL -3. 1 p.m. ET. 1-2. 58. Sunday, Oct. 2. 2-1

How could you go against the immortal Cooper Rush? All the man does is spot start and win games. Meanwhile, Carson Wentz is doing what he does; a few amazing throws, many non-amazing throws, and a bunch of sacks.

Pick: Dallas 25, Washington 16

Sunday, Oct. 2. 1-2. 1-2. 36. FOX. 50. DET -4.5. 1 p.m. ET

The Lions should win this game. Much more explosive offensively, and the defensive front should get pressure on Geno Smith.

Pick: Detroit 38, Seattle 23

Sunday, Oct. 2. 1-1-1. 46. IND -3.5. 1 p.m. ET. FOX. 1-2. 35

Pick: Indianapolis 20, Tennessee 18

FOX. NYG -3. 2-1. 57. Sunday, Oct. 2. 2-1. 31. 1 p.m. ET

One of these teams is going to be 3-1. My bet is the Giants, who are at home and have the better quarterback (somehow).

Pick: New York 19, Chicago 16

Sunday, Oct. 2. 3-0. 1 p.m. ET. 2-1. 52. CBS. 54. PHI -6.5

Who would have thought this would be an excellent game? Jacksonville looks like the best team in the AFC South, while the Eagles might be the best team in football. Oh, and it’s Doug Pederson’s return.

Pick: Philadelphia 30, Jacksonville 24

30. CBS. 1-2. 55. PIT -3.5. 1-2. 1 p.m. ET. Sunday, Oct. 2

Zach Wilson is back. Mitch Trubisky is still here. Prepare yourselves for a defensive battle for the ages.

Pick: Pittsburgh 22, New York 16

Sunday, Oct. 2. 2-1. BUF -3. 1 p.m. ET. 2-1. CBS. 26. 16

Best game of the week. Arguably the top two quarterbacks through the first three weeks going at it. Both have accounted for more than 85 percent of their team’s offense. In this matchup, Lamar Jackson gets the best of Josh Allen.

Pick: Baltimore 35, Buffalo 30

1-2. CBS. LAC -5. 13. Sunday, Oct. 2. 0-2-1. 10. 1 p.m. ET

I should have taken the Jaguars last week but didn’t have the guts. I could have a repeat situation on my hands, but the Texans have looked brutal thus far.

Pick: Los Angeles 27, Houston 23

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