DraftKings NFL 2022: Best daily fantasy lineup for Week 16

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Dec 18, 2022; Houston, Texas, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) scores a touchdown during the game against the Houston Texans at NRG Stadium. Mandatory Credit: Troy Taormina-USA TODAY Sports /

This week’s DraftKings lineup features plenty of fantasy studs with plenty of upside, as well as some sleepers. Here is the best lineup for Week 16.

If you’ve missed the fantasy playoffs, don’t fret — DraftKings is still a way to play fantasy football and add a little spice to gamedays.

With each week feeling more and more like playoff football, there are plenty of matchups and players to keep an eye on. Here’s this week’s DraftKings lineup.

Best DraftKings Lineup for Week 16

QB: Patrick Mahomes, Kansas City Chiefs ($8,400)

The MVP favorite has been the overall fantasy QB2 only behind Jalen Hurts. Patrick Mahomes leads the league in passing yards and touchdowns and is yet again on pace to have a historic passing season. Even without Tyreek Hill, the Chiefs’ offense still remains the best in the league.

Because of all this, Mahomes is one of the most expensive DraftKings quarterbacks. However, he’s proven weekly that the cost to get him may just be worth it, as having the best fantasy quarterback can go a long way in DraftKings lineups. We’re taking him up on that offer this week.

Seattle, even with a couple of stud rookie cornerbacks, has given up big passing days. They rank 18th in fantasy points per game allowed to the quarterback and rank as the 17th passing defense. Mahomes has been matchup-proof this far, and with the state of the Chiefs defense deteriorating, he will have plenty of chances to throw the ball.