DraftKings NFL 2022: Best daily fantasy lineup for Week 16

Dec 18, 2022; Houston, Texas, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) scores a touchdown during the game against the Houston Texans at NRG Stadium. Mandatory Credit: Troy Taormina-USA TODAY Sports
Dec 18, 2022; Houston, Texas, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) scores a touchdown during the game against the Houston Texans at NRG Stadium. Mandatory Credit: Troy Taormina-USA TODAY Sports /
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Dec 18, 2022; Charlotte, North Carolina, USA; Pittsburgh Steelers running back Najee Harris (22) scores a touchdown as Carolina Panthers safety Jeremy Chinn (21) defends in the first quarter at Bank of America Stadium. Mandatory Credit: Bob Donnan-USA TODAY Sports
Dec 18, 2022; Charlotte, North Carolina, USA; Pittsburgh Steelers running back Najee Harris (22) scores a touchdown as Carolina Panthers safety Jeremy Chinn (21) defends in the first quarter at Bank of America Stadium. Mandatory Credit: Bob Donnan-USA TODAY Sports /

RB1: Najee Harris, Pittsburgh Steelers ($6,000)

Najee Harris had a bit of a rough start to the 2022 season, having two finishes outside of the top 40. Since then, he’s gotten hot and now ranks as the overall RB15 on the season after rattling off nine-straight top-30 fantasy weeks. The first-round investment that managers made on him seems to finally be paying off.

Due to his lack of overall elite fantasy play, Harris is a little cheaper than most starting running backs. At just $6,000, we were able to select a no-brainer RB1, especially in this week’s matchup against the Las Vegas Raiders, who allow the fifth-most fantasy points per game to running backs. Harris should have no issue outperforming his value this week.

RB2: Isiah Pacheco, Kansas City Chiefs ($5,700)

Isiah Pacheco has been impressive as the Chiefs’ new starting running back. Being one of the hardest runners in the league, he’s genuinely fun to watch play football. He’s been fantasy-relevant as well, having finished in the top 25 in four of the last five weeks.

Pacheco has a favorable matchup against the Seattle Seahawks’ 31st-ranked run defense. Pacheco went up against Houston’s league-worst run defense last week, but the Chiefs were unable to fully capitalize on that matchup. Assuming they don’t make the same mistake again, Pacheco will be a solid second running back in the lineup.