NFL Week 7 Upset Picks: Colts Over 49ers, AFC North Shocker Among Top Predictions

There are three different games in the Week 7 slate with teams that are double-digit underdogs, but that doesn’t mean there aren’t other upsets to pick. 

Last week, our team went 4-1 on our moneyline upset picks, with the Jacksonville Jaguars, Arizona Cardinals, Las Vegas Raiders and Tennessee Titans all coming through with wins. 

That moved our record to 17-8 through the first six weeks, so what do you say we continue to improve that number this week?

Here’s who we are backing in Week 7, with odds via WynnBET Sportsbook:

Indianapolis Colts (+170) at San Francisco 49ers

I will have faith that Carson Wentz can somehow get back to his 2017 form until the end of time and Wentz has inched closer to that level of play in the last few weeks. Wentz won AFC Offensive Player of the Week after he went 11-for-20 for 223 yards, two touchdowns and zero interceptions. 

Wentz hasn’t thrown an interception since Week 2, which is a major feat for a quarterback with a savior complex. On top of Wentz holding onto the ball, Jonathan Taylor has found his stride. 

Taylor ran for nearly 150 yards last week. It was against the Texans, but was still a big step. 

The 49ers are getting Jimmy Garappolo back, and while that may be a return to normalcy, the Colts are in a good rhythm right now. -- Donnavan Smoot

Prior to this season Frank Reich’s teams were 21-12 from Week 6 on and they continued that trend with a win in Week 6 of this year over the Houston Texans. 

The Colts would be winners of three straight games had they not blown a 22-3 lead against the Baltimore Ravens in Week 5, and I think they’ll take advantage of a 49ers team that hasn’t looked impressive at all this season. 

Jimmy Garoppolo may be back, but I’m not convinced that the 49ers are a true contender in the NFC after starting the season 2-3 with their only wins coming over the Detroit Lions and Philadelphia Eagles. -- Peter Dewey

Philadelphia Eagles (+145) at Las Vegas Raiders

This seems like the perfect sell high spot on the Raiders. The team is coming off of an impressive road upset against the Broncos and now face an Eagles team that has struggled against the NFL’s elite, but has competed everywhere else. Jalen Hurts can make some plays with his legs and the offense can get Miles Sanders involved against a Raiders defense that is 27th in explosive rush rate.

The Raiders are a team that I like backing as underdogs but have on interest in playing as favorites. Both offenses should be able to move the ball and I see the Eagles live for an upset. -- Reed Wallach

The Eagles have hung tough in their last two games in a comeback win vs. the Panthers, followed by a short turnaround and six-point loss last Thursday night to the Buccaneers. They now have a few extra days to rest up before traveling to Vegas this Sunday as three point road dogs.

Meanwhile, the Raiders turned the Broncos over four times last week, but that was more of an anomaly than anything. The Raiders will be chalky this week after a dominant upset win in Denver, but I think that was more of a Broncos issue than anything else. I agree with my guy Reed and expect to see a fun back-and-forth offensive game that allows for Jalen Hurts to get out in space.

While we're at it, can we get a combined prop bet for the two Alabama wideout stars, Devonta Smith and Henry Ruggs to each score a touchdown of 20+ yards? -- Ben Heisler

Cincinnati Bengals (+225) at Baltimore Ravens

I’m getting aggressive on my NFL upset pick in Week 7, and I’m going to sell high on the Ravens by backing the Bengals on the moneyline.

Believe it or not, the Cincinnati defense has been among the best in the NFL through the first six weeks. They rank second in opponent yards per play at 5.1, and what might be even more important, is that they rank seventh in opponent yards per carry at 3.9. That’s a good recipe if you’re hoping to stop the Ravens rush attack.

Joe Burrow can also exploit this Ravens secondary that ranks 21st in the NFL in opponent yards per pass attempt at 7.3.

I’m impressed by this Bengals team, and with everyone singing the praises of the Baltimore Ravens after a few impressive outings, I think it's a good time to go against them. -- Iain MacMillan

NFL Upset Picks to Date:

LAST WEEK: 4-1

SEASON RECORD: 17-8