Davis, who has been dealing with a nagging hamstring injury, was a true game time decision and after warming up on the field, he just didn’t feel himself forcing the Niners to deactivate him for their game against the Indianapolis Colts.
Per Cam Inman:
Vernon Davis not playing for
#49ers for first time in 99 games
While Davis was somewhat of a forgotten man for the Niners after they moved on from Alex Smith, the talented tight end reemerged as a force late in the season (and during the postseason) for the 49ers and was continuing that trend through the first two weeks of the 2013 season.
The 49ers had said earlier in the week they planned to establish the run game against the Colts, so the loss of Davis won’t help considering Davis isn’t only a great pass catching tight end, but also a stout run blocker.