The Houston Rockets expected big things after signing Dwight Howard in the offseason, and they had a solid 54-28 record in the Western Conference last season. Howard and company couldn’t get past the Portland Trail Blazers in the first round of the playoffs though, ending their season early.
All times Eastern
| Date | Opponent | Time |
| Oct. 28 | at Los Angeles | 10:30 |
| Oct. 29 | at Utah | 9:00 |
| Nov. 1 | Boston | 8:00 |
| Nov. 3 | at Philadelphia | 7:00 |
| Nov. 4 | at Miami | 7:30 |
| Nov. 6 | San Antonio | 8:00 |
| Nov. 8 | Golden State | 8:00 |
| Nov. 12 | at Minnesota | 10:00 |
| Nov. 14 | Philadelphia | 8:00 |
| Nov. 16 | at Oklahoma City | 7:00 |
| Nov. 17 | at Memphis | 8:00 |
| Nov. 19 | Los Angeles | 9:30 |
| Nov. 22 | Dallas | 8:00 |
| Nov. 24 | New York | 8:00 |
| Nov. 26 | Sacramento | 8:00 |
| Nov. 28 | Los Angeles | 8:00 |
| Nov. 29 | at Milwaukee | 9:00 |
| Dec. 3 | Memphis | 8:00 |
| Dec. 5 | at Minnesota | 8:00 |
| Dec. 6 | Phoenix | 8:00 |
| Dec. 10 | at Golden State | 10:30 |
| Date | Opponent | Time |
| Dec. 11 | at Sacramento | 10:30 |
| Dec. 13 | Denver | 8:00 |
| Dec. 17 | at Denver | 10:30 |
| Dec. 18 | New Orleans | 8:30 |
| Dec. 20 | Atlanta | 8:00 |
| Dec. 22 | Portland | 8:00 |
| Dec. 26 | at Memphis | 8:00 |
| Dec. 28 | at San Antonio | 7:00 |
| Dec. 29 | Washington | 8:00 |
| Dec. 31 | Charlotte | 7:00 |
| Jan. 2 | at New Orleans | 8:00 |
| Jan. 3 | Miami | 8:00 |
| Jan. 5 | at Chicago | 8:00 |
| Jan. 7 | at Cleveland | 7:00 |
| Jan. 8 | at New York | 8:00 |
| Jan. 10 | Utah | 8:00 |
| Jan. 12 | at Brooklyn | 7:30 |
| Jan. 14 | at Orlando | 7:00 |
| Jan. 15 | Oklahoma City | 8:00 |
| Jan. 17 | Golden State | 8:00 |
| Jan. 19 | Indiana | 5:30 |
|
| Date | Opponent | Time |
| Mar. 11 | at Portland | 10:30 |
| Mar. 12 | at Utah | 9:00 |
| Mar. 15 | at Los Angeles | 3:30 |
| Mar. 17 | Orlando | 8:00 |
| Mar. 19 | Denver | 8:00 |
| Mar. 21 | Phoenix | 8:00 |
| Mar. 23 | at Indiana | 7:00 |
| Mar. 25 | at New Orleans | 8:00 |
| Mar. 27 | Minnesota | 8:00 |
| Mar. 29 | at Washington | 6:00 |
| Mar. 30 | at Toronto | 7:30 |
| Apr. 1 | Sacramento | 8:00 |
| Apr. 2 | at Dallas | 8:30 |
| Apr. 5 | at Oklahoma City | 1:00 |
| Apr. 8 | at San Antonio | 8:30 |
| Apr. 10 | San Antonio | 8:00 |
| Apr. 12 | New Orleans | 7:00 |
| Apr. 13 | at Charlotte | 7:00 |
| Apr. 15 | Utah | 8:00 |