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NCAA Tournament Sweet 16 schedule: How to watch and betting lines

By Mike Phillips

INDIANAPOLIS, INDIANA - MARCH 22: Jalen Suggs #1 of the Gonzaga Bulldogs shoots against Kur Kuath #52 of the Oklahoma Sooners in the second round game of the 2021 NCAA Men's Basketball Tournament at Hinkle Fieldhouse on March 22, 2021 in Indianapolis, Indiana. (Photo by Andy Lyons/Getty Images)
INDIANAPOLIS, INDIANA - MARCH 22: Jalen Suggs #1 of the Gonzaga Bulldogs shoots against Kur Kuath #52 of the Oklahoma Sooners in the second round game of the 2021 NCAA Men's Basketball Tournament at Hinkle Fieldhouse on March 22, 2021 in Indianapolis, Indiana. (Photo by Andy Lyons/Getty Images) /
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The Sweet 16 schedule is set with eight incredible NCAA Tournament matchups set for this weekend.

After an upset-filled start to the NCAA Tournament, the Sweet 16 promises to be an extremely interesting round of March Madness play. Gonzaga and Baylor are looking to complete their seemingly pre-ordained trips to the Final Four while a litany of challengers from the Pac-12, SEC, Big East and mid-major conferences seek to crash the party.

Let’s take a look at all the information you need to know about the Sweet 16 matchups set to be played on Saturday and Sunday, including game venues, broadcast info, and betting lines. All games can be streamed on Paramount+ (for CBS games) or the NCAA’s March Madness Live while all odds referenced in this story are provided courtesy of the FanDuel Sportsbook.

March Madness: Sweet 16 matchups on Saturday, March 27

Midwest Region – No. 12 Oregon State vs. No. 8 Loyola-Chicago

  • Time: 2:40 p.m. ET
  • Venue: Bankers Life Fieldhouse
  • TV: CBS
  • Line: Loyola-Chicago -6.5

Oregon State used its offensive firepower to blow past Tennessee and Oklahoma State but their run comes to an end here. Porter Moser’s team is a legitimate Final Four threat and won’t be intimidated by the Beavers.

Prediction: Loyola Chicago 66, Oregon State 60

South Region – No. 5 Villanova vs. No. 1 Baylor

  • Time: 5:15 p.m. ET
  • Venue: Hinkle Fieldhouse
  • TV: CBS
  • Line: Baylor -6.5

Jay Wright deserves a ton of credit for getting the Wildcats here without Collin Gillespie but going from Winthrop and North Texas to Baylor is a massive leap in competition. The Bears get the job done convincingly.

Prediction: Baylor 78, Villanova 65

South Region – No. 15 Oral Roberts vs. No. 3 Arkansas

  • Time: 7:25 p.m. ET
  • Venue: Bankers Life Fieldhouse
  • TV: TBS
  • Line: Arkansas -11.5

These teams met in the regular season and Oral Roberts led by ten at the break before Arkansas rallied to win by 11. That familiarity really hurts the Golden Eagles, whose Cinderella ride comes to an end against the deep Razorbacks.

Prediction: Arkansas 88, Oral Roberts 74

Midwest Region – No. 11 Syracuse vs. No. 2 Houston

  • Time: 9:55 p.m. ET
  • Venue: Hinkle Fieldhouse
  • TV: TBS
  • Line: Houston -6

The five days between games will give Kelvin Sampson plenty of time to prepare the Cougars for Syracuse’s 2-3 zone, eliminating a huge advantage for the Orange. Houston will utilize its stellar defense to shut down Buddy Boeheim and advance to the Elite Eight.

Prediction: Houston 70, Syracuse 60

March Madness: Sweet 16 matchups on Sunday, March 28

West Region – No. 5 Creighton vs. No. 1 Gonzaga

  • Time: 2:10 p.m. ET
  • Venue: Hinkle Fieldhouse
  • TV: CBS
  • Line: Gonzaga -13.5

The Bluejays have the firepower to make this game interesting but Creighton’s defense won’t be able to slow down the Bulldogs. Gonzaga takes care of business with another double-digit win.

Prediction: Gonzaga 92, Creighton 78

East Region – No. 4 Florida State vs. No. 1 Michigan

  • Time: 5:00 p.m. ET
  • Venue: Bankers Life Fieldhouse
  • TV: CBS
  • Line: Michigan -3

This could be the best game of the day as Florida State’s depth should give them plenty of ammunition to slow down the Wolverines. Isaiah Livers’ health looms large here and if he plays it could be the difference-maker for Michigan, but expect this contest to go down to the wire.

Prediction: Florida State 79, Michigan 77

East Region – No. 11 UCLA vs. No. 2 Alabama

  • Time: 7:15 p.m. ET
  • Venue: Hinkle Fieldhouse
  • TV: TBS
  • Line: Alabama -5.5

UCLA’s run to the Sweet 16 has been impressive but they haven’t played a team as strong as Alabama yet. The Crimson Tide got back on track from a sluggish first-round performance against Iona by blowing out Maryland and should overwhelm the Bruins.

Prediction: Alabama 85, UCLA 73

West Region – No. 7 Oregon vs. No. 6 USC

  • Time: 9:45 p.m. ET
  • Venue: Bankers Life Fieldhouse
  • TV: TBS
  • Line: USC -1

This Pac-12 showdown should be a lot of fun as Oregon and USC made statements by blowing out Iowa and Kansas to get here. These teams met just once in the regular season, with the Ducks winning in double overtime, so this contest should be in line for another fantastic finish to wrap the Sweet 16 slate.

Prediction: Oregon 85, USC 82

dark. Next. 20 biggest upsets in the history of March Madness

For more NCAA basketball news, analysis, opinion and features, check out more from the FanSided college basketball section to stay on top of the latest action.

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