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College football expert picks against the spread for Week 5’s Top 25 games

Sep 6, 2021; Atlanta, Georgia, USA; Mississippi Rebels quarterback Matt Corral (2) shows emotion against the Louisville Cardinals in the second half at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-USA TODAY Sports
Sep 6, 2021; Atlanta, Georgia, USA; Mississippi Rebels quarterback Matt Corral (2) shows emotion against the Louisville Cardinals in the second half at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-USA TODAY Sports
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College football picks against the spread Week 5
Wake Forest Demon Deacons. Mandatory Credit: Geoff Burke-USA TODAY Sports

College football expert picks against the spread and the total of every Week 5 game, including Ole Miss-Alabama, Cincinnati-Notre Dame, Arkansas-Georgia and more.

There are going to be good weeks and bad weeks when you’re making college football picks against the spread. Week 5 could be a good week as we have some tasty matchups, including three games featuring two top-12 teams in the AP Top 25. But we definitely need to bounce back after how last week went.

Against the spread, our picks went just 8-12-0. Even worse, our strong start in betting the point totals went by the wayside with a 9-11-0 week. That puts us at 33-39-1 against the spread, 39-30-4 against totals and 72-69-5 overall on the season. Shall we improve on all that? Let’s get on it.

We’re making college football picks against the spread and on point totals for Week 5.

Note: All odds are via WynnBET. For more betting content and info, visit BetSided.

Week 5 college football expert picks against the spread: No. 25-21

Boston College (+14.5) at 25 Clemson – Under 46.0

Even with Dennis Grosel at quarterback for Boston College, this is too many points for Clemson. The Tigers offense has struggled and the Eagles have a quality defense thus far. Moreover, without Will Shipley, that’s one of the only reliable offensive elements now removed. This is going to be another slugfest and, even if Clemson wins, I don’t see it being by more than 10 points.

Louisville at 24 Wake Forest (-6.5) – Over 62.0

Trusting Wake Forest is never the best feeling but the Deacs have been in control of virtually every second of every game they’ve played this season. Louisville will get their points because they have the talent to accomplish that. However, their defense will have fewer answers than Wake’s will have, which is how we get to both of these picks hitting.

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Louisiana Tech (+20.5) at 23 NC State – Under 54.0

An obvious letdown spot for the Wolfpack in this game against a Louisana Tech team that only lost to Mississippi State — who beat NC State — by a point. I expect Dave Doren’s group to win pretty comfortably but they’ll ride their defense and have a bit of a letdown as it’s closer than this line would suggest.

22 Auburn at LSU (-3.5) – Over 55.5

LSU’s offense has admittedly been inconsistent but the one thing they’ve consistently produced is explosive plays. Seeing Auburn’s defense allow Georgia State to move the ball as consistently as they did gives me confidence in Max Johnson. On top of that, TJ Finley might be an upgrade over Bo Nix but no quarterback option for Auburn gives me any type of belief they can win in Death Valley.

21 Baylor (+3.5) at 19 Oklahoma State – Under 47.5

This is one of those games where the teams are closely matched enough that I was always going to take whichever team was getting points. In this case, it’s Baylor. I’m forecasting a bit of a defensive showcase between these two teams and getting more than a field goal cushion with the Bears seems like a good spot.