College football expert picks Week 10: Picks against the spread for every Top 25 game

College football expert picks for Week 10 as we tackle every Top 25 game of the week and pick against the spread and point total.

In terms of name-brand, big-time matchups, college football is lacking in Week 10 in comparison to last week. After all, while fans were treated to numerous Top 25 matchups a week ago now only have one game in Week 10 featuring two ranked teams. That’s okay, though, because it’s also noteworthy that there is only one Top 25 team not in action, giving us many opportunities with our college football expert picks against the spread.

We didn’t make up any ground last week with our picks and, frankly, it didn’t turn out how I would’ve liked. The college football expert picks against the spread went only 7-12 but we continued to slay totals with a 12-7 showing for the week. Against the spread, we are now 73-91-1 on the year but an impressive 90-71-4 betting totals, putting us at 163-162-5 overall for the 2021 season.

Let’s try to make up more ground and let November be a month that pushes us over the top with our Week 10 college football expert picks against the spread. Note: All odds are via WynnBET. For more betting info and content, visit BetSided.

Top 25 teams not in action in Week 10: Oklahoma (8)

College football expert picks against the spread for Week 10 Top 25 matchups

25 Pittsburgh (-21.0) at Duke – Over 64.0

Pitt is coming off of a bad loss to Miami just when you started to believe in the Panthers. However, Duke is a far worse team and Kenny Pickett should lead a bounce-back performance while the defense isn’t good enough to keep this game under.

24 San Diego State (-7.5) at Hawaii – Under 45.0

Hawaii’s offense isn’t what we’ve seen from them in years past and the San Diego State defense feasts on that type of opponent. This game won’t be all that pretty but the Aztecs should bounce back from a loss of their own in a low-scoring affair.

Boise State at 23 Fresno State (-5.0) – Over 60.5

Though we haven’t seen Fresno State be perfect this season, it seems like this line is buying too much into a win about a month ago for Boise State as they beat BYU. In the two games since, though, they lost to Air Force and only beat Colorado State by single digits. Give me the Bulldogs in a relatively high-scoring game.

WynnBET Promo: Bet $1, Win $100 if any NFL or college football team scores. Claim offer now.

22 Iowa (-11.5) at Northwestern – Under 41.0

For as much as the star has fallen for the Hawkeyes in recent weeks, this is still a good defense. On the flip side, Northwestern is just bad all-around. This will be a game Big Ten non-fans make fun of but the cover and under for Iowa just fit right.

21 Wisconsin (-13.0) at Rutgers – Under 37.5

Basically take what we said for the previous game and apply it to this one. Wisconsin has shown a tad more life, which makes such a low total a little scary. On the whole, though, the Badgers feel right in the range to win this one something like 21-3.

Illinois at 20 Minnesota (-14.5) – Over 43.5

One of the biggest shocks of the playoff rankings was Minnesota cracking not just the Top 25 but the top 20. That shouldn’t change against an Illinois team that has been struggling mightily as of late. But the Illini run game should do enough to get this over a low total.

19 NC State (-2.5) at Florida State – Over 55.5

The Seminoles have undeniably been playing better over the past couple of weeks but, with some players potentially missing practice with the flu this week, NC State feels like the overall better team and the safe bet here.

Tennessee (Pick ‘Em) at 18 Kentucky – Over 57.0

Honestly, the impetus for this pick is the fact that Kentucky’s record is starting to look a bit too much like it’s smoke and mirrors. Plus, Tennessee has started to really come on strong offensively of late and the passing game can attack the vulnerabilities of the Wildcats.

17 Mississippi State (+4.0) at Arkansas – Over 53.5

There have been good points made that the Razorbacks dropping eight on defense could challenge Mike Leach’s Bulldogs but that’s a risk I’m willing to take. Mississippi State has been looking much better lately and we could see them make another statement in Fayetteville.

Liberty at 16 Ole Miss (-9.5) – Over 67.5

Some people are going to say that this won’t be as high-scoring as expected, so the total does scare me. And there is a world where Hugh Freeze has Malik Willis and Co. ready for the game of their lives. At the end of the day, though, Lane Kiffin should have his Rebels ready for a dogfight and will get the job done.

Idaho State at 15 BYU – No Line

With no line for this game, we can assume that BYU is expected to roll handily. And truthfully, anything other than that would be more than a little bit of a surprise.

13 Auburn at 14 Texas A&M (-4.5) – Under 49.0

We’re going to learn a lot about Auburn and Texas A&M from this game. They have been rolling lately, but largely against some of the most suspect defenses in the SEC. Things change in this matchup but I trust the Aggies defense just a bit more to win out. The under is my strongest play here, though.

12 Baylor (-6.5) at TCU – Under 58.5

In all honesty, this is a play based on the coaching change for the Horned Frogs. We know Jerry Kill from past stops and he’s going to run, run and run some more. That’ll keep the total low but should also play right into Baylor’s hands for the Bears to get the cover.

11 Oklahoma State at West Virginia (+3.0) – Under 48.5

Something has to come crashing down for Oklahoma State at some point soon and getting West Virginia in Morgantown seems like a prime spot for that to happen. The Mountaineers have been tough at home all year and will remain the same on Saturday.

Navy (+21.0) at 10 Notre Dame – Under 47.0

Just in the simplest terms, this feels like too many points for Notre Dame in a game where Navy is going to try and limit possessions. It also has the makings of a sleepy spot for the Irish and, with the under in play, 21 points is too big of a line.

9 Wake Forest at North Carolina (-2.5) – Over 77.0

This is like the Oprah’s favorite things of touchdowns that’s going to happen in this game — you get a touchdown, you get a touchdown! With the Tar Heels at home and the fact that this isn’t a conference game because of silly old rules, this feels like a hilarious spot for Wake to lose and still be undefeated in conference play despite losing to an ACC team.

Indiana at 7 Michigan (-19.5) – Over 50.5

Michigan has been money at home and my gut would say that Jim Harbaugh’s team should be ready to go out against a pretty mediocre-to-bad Indiana team and take care of business with a statement win after the tough loss a week ago.

Tulsa at 6 Cincinnati (-23.0) – Under 55.0

In recent weeks, I’d been preaching that Cincinnati needed to cover these large spreads to impress the CFP committee. After coming in at No. 6 in the first rankings, that is even more important. The Bearcats need a wholly dominant performance at home, especially with the GameDay crew in town.

5 Ohio State at Nebraska (+14.5) – Under 67.5

Nebraska has been better than their record would say to this point and the crowd in Lincoln should be absolutely rocking for this one. Ohio State’s offense has been grounded a tad against better defenses, which the Huskers have. This is within two scores and not as high-scoring as the total would indicate.

4 Oregon (-7.0) at Washington – Over 51.0

After Jimmy Lake’s comments about Oregon not being an academic institution, my gut tells me that Mario Cristobal is going to have his Ducks ready to go on the road and lay the absolute smackdown on a pretty ho-hum Huskies team.

3 Michigan State (-3.0) at Purdue – Over 53.5

Even though Purdue has been the giant killer, they’ve looked pretty pedestrian since beating Iowa a few weeks ago. Michigan State has enough ability to make explosive plays to get the win in this game but I do expect the Boilermakers to at least make some runs and big plays to hit the over.

LSU at 2 Alabama (-28.5) – Under 66.5

With the spread this high for an SEC rivalry game, I don’t feel great about it but Alabama is just miles better than LSU at this point. I think the defense shuts down the erratic Tigers offense and the Crimson Tide essentially have their way in Tuscaloosa.

Missouri at 1 Georgia (-39.0) – Under 59.0

I’m not all that confident in Georgia covering -39.0 but, at the same time, I truly don’t think that Missouri is getting on the scoreboard in this game. As such, the under is the most confident play.

For more NCAA football news, analysis, opinion and unique coverage by FanSided, including Heisman Trophy and College Football Playoff rankings, be sure to bookmark these pages.