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NFL Week 12 2021: Picks and predictions for every game

By Matt Verderame

GREEN BAY, WISCONSIN - NOVEMBER 14: Aaron Rodgers #12 of the Green Bay Packers reacts in the first half against the Seattle Seahawks at Lambeau Field on November 14, 2021 in Green Bay, Wisconsin. (Photo by Patrick McDermott/Getty Images)
GREEN BAY, WISCONSIN - NOVEMBER 14: Aaron Rodgers #12 of the Green Bay Packers reacts in the first half against the Seattle Seahawks at Lambeau Field on November 14, 2021 in Green Bay, Wisconsin. (Photo by Patrick McDermott/Getty Images) /
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We’re heading down the stretch of the 2021 NFL season with Thanksgiving upon us. Here’s out Week 12 picks of the games this weekend.

As always, all odds courtesy our great partners at WynnBet.

12:30 p.m. ET. Thursday, Nov. 25. 0-9-1. 50. 3-7. 57. FOX. CHI -3.5

If you watch this game, you either hate your family with a blinding rage, or it’s a cry for help.

Pick: Chicago 19, Detroit 12, America 0

DAL -7. 28. Thursday, Nov. 25. 123. 7-3. 4:30 p.m. ET. 5-5. CBS

Dallas needs to bounce back after going without a touchdown in Kansas City. The Raiders make for a good pigeon, as they’re completely falling apart.

Pick: Dallas 32, Las Vegas 20

5-5. 15. 6-4. Thursday, Nov. 25. 8:20 p.m. ET. 16. NBC. DAL -4.5

Buffalo and New Orleans are both struggling mightily, but the Bills still have a top-tier quarterback. The Saints have Trevor Siemian.

Pick: Buffalo 27, New Orleans 17

44. Sunday, Nov. 28. 2-8. 52. ATL -1. FOX. 1 p.m. ET. 4-6

Call the FBI. Call the local police department. Take your TV and throw it into the street. Do it all.

Pick: Atlanta 20, Jacksonville 19

CBS. 56. CIN -3.5. 5-4-1. 55. Sunday, Nov. 28. 6-4. 1 p.m. ET

Huge matchup in the AFC North and playoff picture at large. Cincinnati can really solidify itself with a win, while the Steelers can leapfrog the Bengals with a victory.

Pick: Cincinnati 26, Pittsburgh 23

47. NE -6. CBS. 7-4. 35. Sunday, Nov. 28. 1 p.m. ET. 8-3

Best game of the early slate. New England is playing great defense and running the ball at will, while Mac Jones continues to be efficient. Right now, the Titans are limited offensively. Not good when facing Bill Belichick.

Pick: New England 24, Tennessee 16

87. 59. CAR -1. 5-6. Sunday, Nov. 28. 4-7. 1 p.m. ET. FOX

Whoever loses this game is done. Take the more talented team. Also, the Dolphins can’t block, and the Panthers have a terrific pass rush.

Pick: Carolina 23, Miami 17

30. 10. 1 p.m. ET. 2-8. CBS. Sunday, Nov. 28. 2-8. HOU -2.5

Listen, we’re here for you. Don’t do this. It’s not too late to realize this is the worse choice you can make this weekend.

Pick: Houston 28, New York 23

3-7. 5-6. 54. FOX. Sunday, Nov. 28. 31. PHI -3. 1 p.m. ET

Philadelphia has a real chance to make the playoffs. The Eagles have the Giants twice, Football Team twice, the Jets and host the Cowboys. That could easily be 4-5 wins.

Pick: Philadelphia 30, New York 20

48. Sunday, Nov. 28. 6-5. 1 p.m. ET. 7-3. FOX. 46. TB -2.5

Quietly a very intriguing game. The Bucs are fighting for home-field advantage in the NFC, while the Colts are suddenly peaking after a really rough start to the year.

Pick: Tampa Bay 31, Indianapolis 27

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