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NFL Week 13 2021: Picks and predictions for every game

By Matt Verderame

NEW ORLEANS, LOUISIANA - NOVEMBER 25: Josh Allen #17 of the Buffalo Bills throws a pass during the fourth quarter in the game against the New Orleans Saints at Caesars Superdome on November 25, 2021 in New Orleans, Louisiana. (Photo by Chris Graythen/Getty Images)
NEW ORLEANS, LOUISIANA - NOVEMBER 25: Josh Allen #17 of the Buffalo Bills throws a pass during the fourth quarter in the game against the New Orleans Saints at Caesars Superdome on November 25, 2021 in New Orleans, Louisiana. (Photo by Chris Graythen/Getty Images) /
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It’s time to make our NFL Week 13 picks, and the Monday night game takes center stage with the Buffalo Bills hosting the New England Patriots.

As always, all odds are provided by our great partners at WynnBet.

Thursday, Dec. 2. 5-6. 15. 8:20 p.m. ET. 7-4. NFLN. DAL -4.5. 123

The Cowboys are getting healthier and the Saints … are not. Dallas’ offense will be too much for New Orleans.

Pick: Dallas 29, New Orleans 20

Sunday, Dec. 5. IND -9. 10. 1 p.m. ET. 6-6. 46. CBS. 2-9

If the Colts are going to make the playoffs, they can’t lose a game to the Texans. Don’t expect much resistance from Houston.

Pick: Indianapolis 31, Houston 19

31. FOX. Sunday, Dec. 5. MIA -3. 1 p.m. ET. 5-7. 59. 4-7

The loser of this game is finished. Miami has won four straight, and has the Jets next week. Things could get interesting on South Beach.

Pick: Miami 23, New York 6

8-3. Sunday, Dec. 5. 5-6. TB -11. 1 p.m. ET. 48. FOX. 44

Hide the kids. The Buccaneers are about to go on a run against a soft schedule while the Falcons might be the least-talented 5-6 team of all time.

Pick: Tampa Bay 34, Atlanta 24

Sunday, Dec. 5. 0-10-1. 50. MIN -7. 1 p.m. ET. 5-6. 60. FOX

If there’s any decent team that could lose to the Lions, it’s the Vikings. Let’s not forget Detroit lost on a last-second field goal in the first matchup.

Pick: Minnesota 25, Detroit 19

13. CBS. 7-4. 56. CIN -3. 1 p.m. ET. 6-5. Sunday, Dec. 5

Really intriguing and important game. The Bengals should be able to run the ball at will with Joe Mixon and get enough pressure on Justin Herbert.

Pick: Cincinnati 34, Los Angeles 27

9-2. Sunday, Dec. 5. 4-7. 1 p.m. ET. 32. FOX. 57. AZ -8

There’s no chance the Bears are beating the Cardinals off their bye week. Chicago has looked ready for the offseason for a month now.

Pick: Arizona 30, Chicago 13

5-7. FOX. 1 p.m. ET. 54. Sunday, Dec. 5. 3-8. 30. PHI -6.5

Philadelphia has to win to stay in the NFC playoff picture. The Eagles should handle business against the Jets and do exactly that.

Pick: Philadelphia 28, New York 20

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